Reprogramming of profibrotic macrophages for treatment of bleomycin‐induced pulmonary fibrosis

Reprogramming of profibrotic macrophages for treatment of bleomycin‐induced pulmonary fibrosis

Abstract Fibrotic diseases cause organ failure that lead to ~45% of all deaths in the United States. Activated macrophages stimulate fibrosis by secreting cytokines that induce fibroblasts to synthesize collagen and extracellular matrix proteins. Although suppression of macrophage‐derived cytokine p...

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Bibliographic Details
Main Authors: Fenghua Zhang, Ehab A Ayaub, Bingbing Wang, Estela Puchulu‐Campanella, Yen‐Hsing Li, Suraj U Hettiarachchi, Spencer D Lindeman, Qian Luo, Sasmita Rout, Madduri Srinivasarao, Abigail Cox, Konstantin Tsoyi, Cheryl Nickerson‐Nutter, Ivan O Rosas, Philip S Low
Format: Article
Language:English
Published: Springer Nature 2020-06-01
Series:EMBO Molecular Medicine
Subjects:
bleomycin
folate receptor β
idiopathic pulmonary fibrosis
macrophages
toll‐like receptor 7
Online Access:https://doi.org/10.15252/emmm.202012034
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