Chromatin compaction during confined cell migration induces and reshapes nuclear condensates

Abstract Cell migration through small constrictions during cancer metastasis requires significant deformation of the nucleus, with associated mechanical stress on the nuclear lamina and chromatin. However, how mechanical deformation impacts various subnuclear structures, including protein and nuclei...

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Bibliographic Details
Main Authors: Jessica Z. Zhao, Jing Xia, Clifford P. Brangwynne
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54120-5
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