Chromatin compaction during confined cell migration induces and reshapes nuclear condensates
Abstract Cell migration through small constrictions during cancer metastasis requires significant deformation of the nucleus, with associated mechanical stress on the nuclear lamina and chromatin. However, how mechanical deformation impacts various subnuclear structures, including protein and nuclei...
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| Main Authors: | Jessica Z. Zhao, Jing Xia, Clifford P. Brangwynne |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-54120-5 |
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