Long-term follow-up results of a pilot study for nodular basal cell carcinoma with PDT using partial home treatment protocol
Significance: Evaluate a photodynamic therapy (PDT) protocol for low-risk basal cell carcinoma (BCC) treatment that requires less time spent at the hospital and is less painful. Approach: Eight BCCs were selected, debulked, and received 20 % methyl aminolevulinate cream. After 3 h, the first irradia...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100023006579 |
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| author | Ana Gabriela Salvio Mirian D Stringasci Michelle B Requena Bianca A. Fregolenti Maira Monique da Costa Medeiro Rosilene Guedes Santos Vanderlei Salvador Bagnato |
| author_facet | Ana Gabriela Salvio Mirian D Stringasci Michelle B Requena Bianca A. Fregolenti Maira Monique da Costa Medeiro Rosilene Guedes Santos Vanderlei Salvador Bagnato |
| author_sort | Ana Gabriela Salvio |
| collection | DOAJ |
| description | Significance: Evaluate a photodynamic therapy (PDT) protocol for low-risk basal cell carcinoma (BCC) treatment that requires less time spent at the hospital and is less painful. Approach: Eight BCCs were selected, debulked, and received 20 % methyl aminolevulinate cream. After 3 h, the first irradiation was performed at the hospital (20 min, 150 J/cm2). Then, the cream was re-applied, and a portable irradiation prototype was fixed to the skin around the lesion. After 1.5 h, the patients turned on the prototype for irradiation at home (for 2 h, totalizing 312 J/cm2). Disease-free survival rate and pain score during irradiations were evaluated. Results: The clearance at 30 days after PDT was 87.5 % by histological analysis. The mean follow-up was 21.5 months and the recurrence-free survival at 22 months was 75 %. The pain score was significantly lower at home. Conclusions: A potentially less painful and more comfortable PDT treatment protocol with proven long-term efficiency is presented. A randomized clinical trial has been conducted to confirm these results. |
| format | Article |
| id | doaj-art-6c2215cba9ea4c6b99d9df7c03dafb11 |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-6c2215cba9ea4c6b99d9df7c03dafb112024-12-11T05:55:21ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-02-0145103930Long-term follow-up results of a pilot study for nodular basal cell carcinoma with PDT using partial home treatment protocolAna Gabriela Salvio0Mirian D Stringasci1Michelle B Requena2Bianca A. Fregolenti3Maira Monique da Costa Medeiro4Rosilene Guedes Santos5Vanderlei Salvador Bagnato6Skin Department of Amaral Carvalho Hospital, Jaú, Brazil; Sao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, Brazil; Corresponding author at: Skin Department of Amaral Carvalho Hospital, Jaú, Brazil.Sao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, BrazilSao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, BrazilSkin Department of Amaral Carvalho Hospital, Jaú, BrazilSkin Department of Amaral Carvalho Hospital, Jaú, BrazilSkin Department of Amaral Carvalho Hospital, Jaú, BrazilSao Carlos Institute of Physics, University of Sao Paulo, Sao Carlos, Brazil; Department of Biomedical Engineering, Texas A&M University, TX, USASignificance: Evaluate a photodynamic therapy (PDT) protocol for low-risk basal cell carcinoma (BCC) treatment that requires less time spent at the hospital and is less painful. Approach: Eight BCCs were selected, debulked, and received 20 % methyl aminolevulinate cream. After 3 h, the first irradiation was performed at the hospital (20 min, 150 J/cm2). Then, the cream was re-applied, and a portable irradiation prototype was fixed to the skin around the lesion. After 1.5 h, the patients turned on the prototype for irradiation at home (for 2 h, totalizing 312 J/cm2). Disease-free survival rate and pain score during irradiations were evaluated. Results: The clearance at 30 days after PDT was 87.5 % by histological analysis. The mean follow-up was 21.5 months and the recurrence-free survival at 22 months was 75 %. The pain score was significantly lower at home. Conclusions: A potentially less painful and more comfortable PDT treatment protocol with proven long-term efficiency is presented. A randomized clinical trial has been conducted to confirm these results.http://www.sciencedirect.com/science/article/pii/S1572100023006579Nodular basal cell carcinomaMethyl aminolevulinatePhotodynamic therapyHome treatment |
| spellingShingle | Ana Gabriela Salvio Mirian D Stringasci Michelle B Requena Bianca A. Fregolenti Maira Monique da Costa Medeiro Rosilene Guedes Santos Vanderlei Salvador Bagnato Long-term follow-up results of a pilot study for nodular basal cell carcinoma with PDT using partial home treatment protocol Photodiagnosis and Photodynamic Therapy Nodular basal cell carcinoma Methyl aminolevulinate Photodynamic therapy Home treatment |
| title | Long-term follow-up results of a pilot study for nodular basal cell carcinoma with PDT using partial home treatment protocol |
| title_full | Long-term follow-up results of a pilot study for nodular basal cell carcinoma with PDT using partial home treatment protocol |
| title_fullStr | Long-term follow-up results of a pilot study for nodular basal cell carcinoma with PDT using partial home treatment protocol |
| title_full_unstemmed | Long-term follow-up results of a pilot study for nodular basal cell carcinoma with PDT using partial home treatment protocol |
| title_short | Long-term follow-up results of a pilot study for nodular basal cell carcinoma with PDT using partial home treatment protocol |
| title_sort | long term follow up results of a pilot study for nodular basal cell carcinoma with pdt using partial home treatment protocol |
| topic | Nodular basal cell carcinoma Methyl aminolevulinate Photodynamic therapy Home treatment |
| url | http://www.sciencedirect.com/science/article/pii/S1572100023006579 |
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