Extracellular vesicle lyophilization for enhanced distribution to the point of care
Therapeutic extracellular vesicles (EVs) are in clinical trials and if successful, EVs wider use will be largely affected by costs to patients/insurers and accessibility. EV preservation-storage efficiencies directly factor into both of these considerations. EV cryopreservation drives up costs and r...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-06-01
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| Series: | Extracellular Vesicle |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773041724000088 |
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| _version_ | 1846159394371272704 |
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| author | Morgane E. Golan Steven L. Stice |
| author_facet | Morgane E. Golan Steven L. Stice |
| author_sort | Morgane E. Golan |
| collection | DOAJ |
| description | Therapeutic extracellular vesicles (EVs) are in clinical trials and if successful, EVs wider use will be largely affected by costs to patients/insurers and accessibility. EV preservation-storage efficiencies directly factor into both of these considerations. EV cryopreservation drives up costs and relies on the pharmaceutical cold chain, which is expensive and among the most pressing barriers to widespread access of medicines. Lyophilization preserves biological materials at room temperature, thereby enhancing storage while circumventing the cold chain. Here we describe the factors influencing EV storage and lyophilization processes which may improve accessibility of EV therapies. |
| format | Article |
| id | doaj-art-6c1f1ab09fb242b2a450c8fc44b6c8c4 |
| institution | Kabale University |
| issn | 2773-0417 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Extracellular Vesicle |
| spelling | doaj-art-6c1f1ab09fb242b2a450c8fc44b6c8c42024-11-23T06:34:56ZengElsevierExtracellular Vesicle2773-04172024-06-013100041Extracellular vesicle lyophilization for enhanced distribution to the point of careMorgane E. Golan0Steven L. Stice1Regenerative Bioscience Center, Department of Animal and Dairy Science, Rhodes Center for Animal and Dairy Science, University of Georgia, 425 River Road, Athens, GA 30605, USARegenerative Bioscience Center, Department of Animal and Dairy Science, Rhodes Center for Animal and Dairy Science, University of Georgia, 425 River Road, Athens, GA 30605, USA; Aruna Bio Inc, Athens, GA 30601, USA; Corresponding author. Regenerative Bioscience Center, Department of Animal and Dairy Science, Rhodes Center for Animal and Dairy Science, University of Georgia, 425 River Road, Athens, GA 30605, USA.Therapeutic extracellular vesicles (EVs) are in clinical trials and if successful, EVs wider use will be largely affected by costs to patients/insurers and accessibility. EV preservation-storage efficiencies directly factor into both of these considerations. EV cryopreservation drives up costs and relies on the pharmaceutical cold chain, which is expensive and among the most pressing barriers to widespread access of medicines. Lyophilization preserves biological materials at room temperature, thereby enhancing storage while circumventing the cold chain. Here we describe the factors influencing EV storage and lyophilization processes which may improve accessibility of EV therapies.http://www.sciencedirect.com/science/article/pii/S2773041724000088 |
| spellingShingle | Morgane E. Golan Steven L. Stice Extracellular vesicle lyophilization for enhanced distribution to the point of care Extracellular Vesicle |
| title | Extracellular vesicle lyophilization for enhanced distribution to the point of care |
| title_full | Extracellular vesicle lyophilization for enhanced distribution to the point of care |
| title_fullStr | Extracellular vesicle lyophilization for enhanced distribution to the point of care |
| title_full_unstemmed | Extracellular vesicle lyophilization for enhanced distribution to the point of care |
| title_short | Extracellular vesicle lyophilization for enhanced distribution to the point of care |
| title_sort | extracellular vesicle lyophilization for enhanced distribution to the point of care |
| url | http://www.sciencedirect.com/science/article/pii/S2773041724000088 |
| work_keys_str_mv | AT morganeegolan extracellularvesiclelyophilizationforenhanceddistributiontothepointofcare AT stevenlstice extracellularvesiclelyophilizationforenhanceddistributiontothepointofcare |