Multivariate quantitative analysis of glycan impact on IgG1 effector functions

Multivariate quantitative analysis of glycan impact on IgG1 effector functions

Development of novel therapeutic proteins and biosimilars requires a thorough understanding of the relationship between their structure and function. Particularly, how IgG glycosylation affects its effector functions is a point increasingly underscored in guidelines by the World Health Organization...

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Bibliographic Details
Main Authors: Tamara Cvijić, Matej Horvat, Jakob Plahutnik, Ana Golob, Jaka Marušič
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
Antibody therapeutic
BLI
effector functions
glycoengineering
IgG1
multivariate analysis
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2430295
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