Reversal of neuronal tau pathology via adiponectin receptor activation

Reversal of neuronal tau pathology via adiponectin receptor activation

Abstract Changes in brain mitochondrial metabolism are coincident with functional decline; however, direct links between the two have not been established. Here, we show that mitochondrial targeting via the adiponectin receptor activator AdipoRon (AR) clears neurofibrillary tangles (NFTs) and rescue...

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Bibliographic Details
Main Authors: Eric R. McGregor, Danny J. Lasky, Olivia J. Rippentrop, Josef P. Clark, Samantha Wright, Mathew V. Jones, Rozalyn M. Anderson
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-07391-z
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