ITIH4 alleviates OVA-induced asthma by regulating lung-gut microbiota

ITIH4 alleviates OVA-induced asthma by regulating lung-gut microbiota

Abstract Background Inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4), a Type 2 acute phase protein, is critical for resolving inflammation and promoting tissue repair. While its role in chronic respiratory diseases is recognized, its effects on asthma remain unclear. This study investigated the e...

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Main Authors: Yi-Hsuan Liu, Yueh-Lun Lee, Chia-Li Han, Yu-Chun Lo, Zih-An Liao, Yu-Syuan Shih, Yi-Wen Lin, Syue-Wei Peng, Kang-Yun Lee, Shu-Chuan Ho, Sheng-Ming Wu, Cheng-Wei Lin, Kian Fan Chung, Jer-Hwa Chang, Hsiao-Chi Chuang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Medicine
Subjects:
Airway hyperresponsiveness
Inflammation
Microbiome
Short-chain fatty acid
Th2
Online Access:https://doi.org/10.1186/s10020-025-01270-x
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