Pyrazolo[1,5-a]pyrimidin-7-ones as promising antimicrobial scaffolds: In vitro and in vivo evaluation.

Pyrazolo[1,5-a]pyrimidin-7-ones as promising antimicrobial scaffolds: In vitro and in vivo evaluation.

This study presents a family of pyrazolo[1,5-a]pyrimidin-7-ones as potential antimicrobial agents. Initial screening against Staphylococcus aureus, Escherichia coli, and Candida albicans identified compound 3 as active against S. aureus (MIC₅₀ 1.8 μM). A structure activity relationship study of 35 a...

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Bibliographic Details
Main Authors: Amanda A. Doyle, Mark Kelada, Clara Charleton, Robert Devine, John M.D. Walsh, Ronan Bergin, Kevin Kavanagh, John C. Stephens
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Results in Chemistry
Subjects:
Antimicrobial activity
Anti-MRSA agents
SAR study
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715625003868
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