METTL3, an Independent Adverse Prognostic Factor for AML, Promotes the Development of AML by Modulating the PGC‐1α–MAPK Pathway and PGC‐1α–Antioxidant System Axis

METTL3, an Independent Adverse Prognostic Factor for AML, Promotes the Development of AML by Modulating the PGC‐1α–MAPK Pathway and PGC‐1α–Antioxidant System Axis

ABSTRACT Background m6A represents a prevalent epigenetic modification of mammalian mRNAs. Studies have demonstrated that m6A RNA methylation‐modifying enzymes play crucial roles in the onset and progression of AML. However, their clinical relevance remains undefined, and the mechanisms underlying t...

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Main Authors: Yuqian Tang, Xiaoyan Liu, Wu Ye, Xiaojia Wang, Xiaoyu Wei, Yiwen Du, Ying Zhang, Yuping Gong
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Cancer Medicine
Subjects:
acute myeloid leukemia
m6A RNA methylation
METTL3
PGC‐1α
WTAP
Online Access:https://doi.org/10.1002/cam4.70771
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