Enter the Matrix: Fibroblast-immune cell interactions shape extracellular matrix deposition in health and disease. [version 2; peer review: 1 approved, 2 approved with reservations]
Fibroblasts, non-hematopoietic cells of mesenchymal origin, are tissue architects which regulate the topography of tissues, dictate tissue resident cell types, and drive fibrotic disease. Fibroblasts regulate the composition of the extracellular matrix (ECM), a 3-dimensional network of macromolecule...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2024-12-01
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| Online Access: | https://f1000research.com/articles/13-119/v2 |
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| _version_ | 1841555749685166080 |
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| author | Anthony Altieri Grace V. Visser Matthew B. Buechler |
| author_facet | Anthony Altieri Grace V. Visser Matthew B. Buechler |
| author_sort | Anthony Altieri |
| collection | DOAJ |
| description | Fibroblasts, non-hematopoietic cells of mesenchymal origin, are tissue architects which regulate the topography of tissues, dictate tissue resident cell types, and drive fibrotic disease. Fibroblasts regulate the composition of the extracellular matrix (ECM), a 3-dimensional network of macromolecules that comprise the acellular milieu of tissues. Fibroblasts can directly and indirectly regulate immune responses by secreting ECM and ECM-bound molecules to shape tissue structure and influence organ function. In this review, we will highlight recent studies which elucidate the mechanisms by which fibroblast-derived ECM factors (e.g., collagens, fibrillar proteins) regulate ECM architecture and subsequent immune responses, with a focus on macrophages. As examples of fibroblast-derived ECM proteins, we examine Collagen Triple Helix Repeat Containing 1 (CTHRC1) and Transforming Growth Factor-β-inducible protein (TGFBI), also known as BIGH3. We address the need for investigation into how diverse fibroblast populations coordinate immune responses by modulating ECM, including the fibroblast-ECM-immune axis and the precise molecular mediators and pathways which regulate these processes. Finally, we will outline how novel research identifying key regulators of ECM deposition is critical for therapeutic development for fibrotic diseases and cancer. |
| format | Article |
| id | doaj-art-6b9140c6c9ce4a8aaa394cd99d0418ee |
| institution | Kabale University |
| issn | 2046-1402 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj-art-6b9140c6c9ce4a8aaa394cd99d0418ee2025-01-08T01:00:02ZengF1000 Research LtdF1000Research2046-14022024-12-0113173782Enter the Matrix: Fibroblast-immune cell interactions shape extracellular matrix deposition in health and disease. [version 2; peer review: 1 approved, 2 approved with reservations]Anthony Altieri0Grace V. Visser1Matthew B. Buechler2https://orcid.org/0000-0003-1902-622XImmunology, University of Toronto, Toronto, Ontario, CanadaImmunology, University of Toronto, Toronto, Ontario, CanadaImmunology, University of Toronto, Toronto, Ontario, CanadaFibroblasts, non-hematopoietic cells of mesenchymal origin, are tissue architects which regulate the topography of tissues, dictate tissue resident cell types, and drive fibrotic disease. Fibroblasts regulate the composition of the extracellular matrix (ECM), a 3-dimensional network of macromolecules that comprise the acellular milieu of tissues. Fibroblasts can directly and indirectly regulate immune responses by secreting ECM and ECM-bound molecules to shape tissue structure and influence organ function. In this review, we will highlight recent studies which elucidate the mechanisms by which fibroblast-derived ECM factors (e.g., collagens, fibrillar proteins) regulate ECM architecture and subsequent immune responses, with a focus on macrophages. As examples of fibroblast-derived ECM proteins, we examine Collagen Triple Helix Repeat Containing 1 (CTHRC1) and Transforming Growth Factor-β-inducible protein (TGFBI), also known as BIGH3. We address the need for investigation into how diverse fibroblast populations coordinate immune responses by modulating ECM, including the fibroblast-ECM-immune axis and the precise molecular mediators and pathways which regulate these processes. Finally, we will outline how novel research identifying key regulators of ECM deposition is critical for therapeutic development for fibrotic diseases and cancer.https://f1000research.com/articles/13-119/v2Fibroblasts Fibroblast heterogeneity Extracellular Matrix (ECM) Immunology Macrophages BigH3eng |
| spellingShingle | Anthony Altieri Grace V. Visser Matthew B. Buechler Enter the Matrix: Fibroblast-immune cell interactions shape extracellular matrix deposition in health and disease. [version 2; peer review: 1 approved, 2 approved with reservations] F1000Research Fibroblasts Fibroblast heterogeneity Extracellular Matrix (ECM) Immunology Macrophages BigH3 eng |
| title | Enter the Matrix: Fibroblast-immune cell interactions shape extracellular matrix deposition in health and disease. [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_full | Enter the Matrix: Fibroblast-immune cell interactions shape extracellular matrix deposition in health and disease. [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_fullStr | Enter the Matrix: Fibroblast-immune cell interactions shape extracellular matrix deposition in health and disease. [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_full_unstemmed | Enter the Matrix: Fibroblast-immune cell interactions shape extracellular matrix deposition in health and disease. [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_short | Enter the Matrix: Fibroblast-immune cell interactions shape extracellular matrix deposition in health and disease. [version 2; peer review: 1 approved, 2 approved with reservations] |
| title_sort | enter the matrix fibroblast immune cell interactions shape extracellular matrix deposition in health and disease version 2 peer review 1 approved 2 approved with reservations |
| topic | Fibroblasts Fibroblast heterogeneity Extracellular Matrix (ECM) Immunology Macrophages BigH3 eng |
| url | https://f1000research.com/articles/13-119/v2 |
| work_keys_str_mv | AT anthonyaltieri enterthematrixfibroblastimmunecellinteractionsshapeextracellularmatrixdepositioninhealthanddiseaseversion2peerreview1approved2approvedwithreservations AT gracevvisser enterthematrixfibroblastimmunecellinteractionsshapeextracellularmatrixdepositioninhealthanddiseaseversion2peerreview1approved2approvedwithreservations AT matthewbbuechler enterthematrixfibroblastimmunecellinteractionsshapeextracellularmatrixdepositioninhealthanddiseaseversion2peerreview1approved2approvedwithreservations |