In vivo electrical properties of the healthy liver and the hepatic tumor in a mouse model between 1 Hz and 1 MHz during a thermal treatment
Objective: Understansding the changing patterns of in vivo electrical properties for the target tissue is crucial for the accurate temperature monitoring and the treatment efficacy in thermal therapy. Our research aims to investigate the changing patterns and the reversibility of in vivo electrical...
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2396122 |
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| author | Yitong Guo Weice Wang Weichen Li Junyao Li Mingxu Zhu Ruteng Song Wenjing Zhu Lei Wang Zhenyu Ji Xuetao Shi |
| author_facet | Yitong Guo Weice Wang Weichen Li Junyao Li Mingxu Zhu Ruteng Song Wenjing Zhu Lei Wang Zhenyu Ji Xuetao Shi |
| author_sort | Yitong Guo |
| collection | DOAJ |
| description | Objective: Understansding the changing patterns of in vivo electrical properties for the target tissue is crucial for the accurate temperature monitoring and the treatment efficacy in thermal therapy. Our research aims to investigate the changing patterns and the reversibility of in vivo electrical properties for both healthy livers and liver tumors in a mouse model over a frequency range of 1 Hz to 1 MHz at temperatures between 30 °C to 90 °C.Methods and materials: The mice were anesthetized and the target organ was exposed. An 808-nm near-infrared laser was employed as the heating source to heat the organ in vivo. The four-needle electrode, connected to an impedance analyzer, was utilized to obtain the impedance at varying temperatures, which were monitored by a thermocouple.Results: The findings indicated a gradual decline in impedance with an increase in temperature. Furthermore, the impedance was normalized to that at 30 °C, and the real part of the normalized impedance was defined as the k-values, which range from 0 to 1. The results demonstrated a linear correlation between k-values and temperatures (R2 > 0.9 for livers and R2 > 0.8 for tumors). Significant differences were observed between livers and tumors at 1, 10 and 50 kHz (p < 0.05). Additionally, it was demonstrated that the electrical properties could be reversed when the temperature was below or equal to 45 °C.Conclusion: We believe that these results will contribute to the advancement of radiofrequency ablation systems and the development of techniques for temperature monitoring during liver thermal treatment. |
| format | Article |
| id | doaj-art-6b81a18d4136470bb95a94fa8e93c244 |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-6b81a18d4136470bb95a94fa8e93c2442025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2396122In vivo electrical properties of the healthy liver and the hepatic tumor in a mouse model between 1 Hz and 1 MHz during a thermal treatmentYitong Guo0Weice Wang1Weichen Li2Junyao Li3Mingxu Zhu4Ruteng Song5Wenjing Zhu6Lei Wang7Zhenyu Ji8Xuetao Shi9Department of Biomedical Engineering, Shaanxi Provincial key Laboratory of Bioelectromagnetic Detection and Intelligent Perception, Air Force Medical University, Xi’an, ChinaDepartment of Biomedical Engineering, Shaanxi Provincial key Laboratory of Bioelectromagnetic Detection and Intelligent Perception, Air Force Medical University, Xi’an, ChinaDepartment of Biomedical Engineering, Shaanxi Provincial key Laboratory of Bioelectromagnetic Detection and Intelligent Perception, Air Force Medical University, Xi’an, ChinaDepartment of Biomedical Engineering, Shaanxi Provincial key Laboratory of Bioelectromagnetic Detection and Intelligent Perception, Air Force Medical University, Xi’an, ChinaDepartment of Biomedical Engineering, Shaanxi Provincial key Laboratory of Bioelectromagnetic Detection and Intelligent Perception, Air Force Medical University, Xi’an, ChinaDepartment of Biomedical Engineering, Shaanxi Provincial key Laboratory of Bioelectromagnetic Detection and Intelligent Perception, Air Force Medical University, Xi’an, ChinaDepartment of Biomedical Engineering, Shaanxi Provincial key Laboratory of Bioelectromagnetic Detection and Intelligent Perception, Air Force Medical University, Xi’an, ChinaInstitute of Medical Research, Northwest Polytechnical University, Xi’an, ChinaDepartment of Biomedical Engineering, Shaanxi Provincial key Laboratory of Bioelectromagnetic Detection and Intelligent Perception, Air Force Medical University, Xi’an, ChinaDepartment of Biomedical Engineering, Shaanxi Provincial key Laboratory of Bioelectromagnetic Detection and Intelligent Perception, Air Force Medical University, Xi’an, ChinaObjective: Understansding the changing patterns of in vivo electrical properties for the target tissue is crucial for the accurate temperature monitoring and the treatment efficacy in thermal therapy. Our research aims to investigate the changing patterns and the reversibility of in vivo electrical properties for both healthy livers and liver tumors in a mouse model over a frequency range of 1 Hz to 1 MHz at temperatures between 30 °C to 90 °C.Methods and materials: The mice were anesthetized and the target organ was exposed. An 808-nm near-infrared laser was employed as the heating source to heat the organ in vivo. The four-needle electrode, connected to an impedance analyzer, was utilized to obtain the impedance at varying temperatures, which were monitored by a thermocouple.Results: The findings indicated a gradual decline in impedance with an increase in temperature. Furthermore, the impedance was normalized to that at 30 °C, and the real part of the normalized impedance was defined as the k-values, which range from 0 to 1. The results demonstrated a linear correlation between k-values and temperatures (R2 > 0.9 for livers and R2 > 0.8 for tumors). Significant differences were observed between livers and tumors at 1, 10 and 50 kHz (p < 0.05). Additionally, it was demonstrated that the electrical properties could be reversed when the temperature was below or equal to 45 °C.Conclusion: We believe that these results will contribute to the advancement of radiofrequency ablation systems and the development of techniques for temperature monitoring during liver thermal treatment.https://www.tandfonline.com/doi/10.1080/02656736.2024.2396122Thermal treatmentradiofrequency ablationliver cancerin-vivo electrical propertytemperature monitoring |
| spellingShingle | Yitong Guo Weice Wang Weichen Li Junyao Li Mingxu Zhu Ruteng Song Wenjing Zhu Lei Wang Zhenyu Ji Xuetao Shi In vivo electrical properties of the healthy liver and the hepatic tumor in a mouse model between 1 Hz and 1 MHz during a thermal treatment International Journal of Hyperthermia Thermal treatment radiofrequency ablation liver cancer in-vivo electrical property temperature monitoring |
| title | In vivo electrical properties of the healthy liver and the hepatic tumor in a mouse model between 1 Hz and 1 MHz during a thermal treatment |
| title_full | In vivo electrical properties of the healthy liver and the hepatic tumor in a mouse model between 1 Hz and 1 MHz during a thermal treatment |
| title_fullStr | In vivo electrical properties of the healthy liver and the hepatic tumor in a mouse model between 1 Hz and 1 MHz during a thermal treatment |
| title_full_unstemmed | In vivo electrical properties of the healthy liver and the hepatic tumor in a mouse model between 1 Hz and 1 MHz during a thermal treatment |
| title_short | In vivo electrical properties of the healthy liver and the hepatic tumor in a mouse model between 1 Hz and 1 MHz during a thermal treatment |
| title_sort | in vivo electrical properties of the healthy liver and the hepatic tumor in a mouse model between 1 hz and 1 mhz during a thermal treatment |
| topic | Thermal treatment radiofrequency ablation liver cancer in-vivo electrical property temperature monitoring |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2396122 |
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