Cohort profile: the Oxford Parkinson’s Disease Centre Discovery Cohort MRI substudy (OPDC-MRI)
Purpose The Oxford Parkinson’s Disease Centre (OPDC) Discovery Cohort MRI substudy (OPDC-MRI) collects high-quality multimodal brain MRI together with deep longitudinal clinical phenotyping in patients with Parkinson’s, at-risk individuals and healthy elderly participants. The primary aim is to dete...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2020-08-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/8/e034110.full |
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| author | Ricarda A L Menke Michael Lawton Thomas R Barber Johannes C Klein Clare Mackay Konrad Szewczyk-Krolikowski Michele T Hu Michal Rolinski Ludovica Griffanti Samuel G Evetts Faye Begeti Marie Crabbe Jane Rumbold Richard Wade-Martins |
| author_facet | Ricarda A L Menke Michael Lawton Thomas R Barber Johannes C Klein Clare Mackay Konrad Szewczyk-Krolikowski Michele T Hu Michal Rolinski Ludovica Griffanti Samuel G Evetts Faye Begeti Marie Crabbe Jane Rumbold Richard Wade-Martins |
| author_sort | Ricarda A L Menke |
| collection | DOAJ |
| description | Purpose The Oxford Parkinson’s Disease Centre (OPDC) Discovery Cohort MRI substudy (OPDC-MRI) collects high-quality multimodal brain MRI together with deep longitudinal clinical phenotyping in patients with Parkinson’s, at-risk individuals and healthy elderly participants. The primary aim is to detect pathological changes in brain structure and function, and develop, together with the clinical data, biomarkers to stratify, predict and chart progression in early-stage Parkinson’s and at-risk individuals.Participants Participants are recruited from the OPDC Discovery Cohort, a prospective, longitudinal study. Baseline MRI data are currently available for 290 participants: 119 patients with early idiopathic Parkinson’s, 15 Parkinson’s patients with pathogenic mutations of the leucine-rich repeat kinase 2 or glucocerebrosidase (GBA) genes, 68 healthy controls and 87 individuals at risk of Parkinson’s (asymptomatic carriers of GBA mutation and patients with idiopathic rapid eye movement sleep behaviour disorder-RBD).Findings to date Differences in brain structure in early Parkinson’s were found to be subtle, with small changes in the shape of the globus pallidus and evidence of alterations in microstructural integrity in the prefrontal cortex that correlated with performance on executive function tests. Brain function, as assayed with resting fMRI yielded more substantial differences, with basal ganglia connectivity reduced in early Parkinson’sand RBD. Imaging of the substantia nigra with the more recent adoption of sequences sensitive to iron and neuromelanin content shows promising results in identifying early signs of Parkinsonian disease.Future plans Ongoing studies include the integration of multimodal MRI measures to improve discrimination power. Follow-up clinical data are now accumulating and will allow us to correlate baseline imaging measures to clinical disease progression. Follow-up MRI scanning started in 2015 and is currently ongoing, providing the opportunity for future longitudinal imaging analyses with parallel clinical phenotyping. |
| format | Article |
| id | doaj-art-6b7c4018c7df46b485dce3ac2a5f9b1c |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-6b7c4018c7df46b485dce3ac2a5f9b1c2024-12-01T23:00:12ZengBMJ Publishing GroupBMJ Open2044-60552020-08-0110810.1136/bmjopen-2019-034110Cohort profile: the Oxford Parkinson’s Disease Centre Discovery Cohort MRI substudy (OPDC-MRI)Ricarda A L Menke0Michael Lawton1Thomas R Barber2Johannes C Klein3Clare Mackay4Konrad Szewczyk-Krolikowski5Michele T Hu6Michal Rolinski7Ludovica Griffanti8Samuel G Evetts9Faye Begeti10Marie Crabbe11Jane Rumbold12Richard Wade-Martins133 Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK2Population Health Sciences, University of Bristol3 Oxford Parkinson’s Disease Centre, University of Oxford, Oxford, UK2 Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, University of Oxford, Oxford, UKOxford Health, NHS Foundation Trust, Oxford, Oxfordshire, UK1 Neurological and Musculoskeletal Sciences Division, Southmead Hospital, North Bristol NHS Trust, Bristol, UK1 Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UKInstitute of Clinical Neurosciences, University of Bristol, Bristol, UKDepartment of Psychiatry, University of Oxford, Oxford, UKOxford Parkinson’s Disease Centre, University of Oxford, Oxford, UKNeurology Department, Oxford University Hospitals NHS Foundation Trust, Oxford, UKOxford Parkinson’s Disease Centre, University of Oxford, Oxford, UKOxford Parkinson’s Disease Centre, University of Oxford, Oxford, UKOxford Parkinson’s Disease Centre, University of Oxford, Oxford, UKPurpose The Oxford Parkinson’s Disease Centre (OPDC) Discovery Cohort MRI substudy (OPDC-MRI) collects high-quality multimodal brain MRI together with deep longitudinal clinical phenotyping in patients with Parkinson’s, at-risk individuals and healthy elderly participants. The primary aim is to detect pathological changes in brain structure and function, and develop, together with the clinical data, biomarkers to stratify, predict and chart progression in early-stage Parkinson’s and at-risk individuals.Participants Participants are recruited from the OPDC Discovery Cohort, a prospective, longitudinal study. Baseline MRI data are currently available for 290 participants: 119 patients with early idiopathic Parkinson’s, 15 Parkinson’s patients with pathogenic mutations of the leucine-rich repeat kinase 2 or glucocerebrosidase (GBA) genes, 68 healthy controls and 87 individuals at risk of Parkinson’s (asymptomatic carriers of GBA mutation and patients with idiopathic rapid eye movement sleep behaviour disorder-RBD).Findings to date Differences in brain structure in early Parkinson’s were found to be subtle, with small changes in the shape of the globus pallidus and evidence of alterations in microstructural integrity in the prefrontal cortex that correlated with performance on executive function tests. Brain function, as assayed with resting fMRI yielded more substantial differences, with basal ganglia connectivity reduced in early Parkinson’sand RBD. Imaging of the substantia nigra with the more recent adoption of sequences sensitive to iron and neuromelanin content shows promising results in identifying early signs of Parkinsonian disease.Future plans Ongoing studies include the integration of multimodal MRI measures to improve discrimination power. Follow-up clinical data are now accumulating and will allow us to correlate baseline imaging measures to clinical disease progression. Follow-up MRI scanning started in 2015 and is currently ongoing, providing the opportunity for future longitudinal imaging analyses with parallel clinical phenotyping.https://bmjopen.bmj.com/content/10/8/e034110.full |
| spellingShingle | Ricarda A L Menke Michael Lawton Thomas R Barber Johannes C Klein Clare Mackay Konrad Szewczyk-Krolikowski Michele T Hu Michal Rolinski Ludovica Griffanti Samuel G Evetts Faye Begeti Marie Crabbe Jane Rumbold Richard Wade-Martins Cohort profile: the Oxford Parkinson’s Disease Centre Discovery Cohort MRI substudy (OPDC-MRI) BMJ Open |
| title | Cohort profile: the Oxford Parkinson’s Disease Centre Discovery Cohort MRI substudy (OPDC-MRI) |
| title_full | Cohort profile: the Oxford Parkinson’s Disease Centre Discovery Cohort MRI substudy (OPDC-MRI) |
| title_fullStr | Cohort profile: the Oxford Parkinson’s Disease Centre Discovery Cohort MRI substudy (OPDC-MRI) |
| title_full_unstemmed | Cohort profile: the Oxford Parkinson’s Disease Centre Discovery Cohort MRI substudy (OPDC-MRI) |
| title_short | Cohort profile: the Oxford Parkinson’s Disease Centre Discovery Cohort MRI substudy (OPDC-MRI) |
| title_sort | cohort profile the oxford parkinson s disease centre discovery cohort mri substudy opdc mri |
| url | https://bmjopen.bmj.com/content/10/8/e034110.full |
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