Deep learning-driven brain tumor classification and segmentation using non-contrast MRI
Abstract This study aims to enhance the accuracy and efficiency of MRI-based brain tumor diagnosis by leveraging deep learning (DL) techniques applied to multichannel MRI inputs. MRI data were collected from 203 subjects, including 100 normal cases and 103 cases with 13 distinct brain tumor types. N...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-13591-2 |
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| author | Nan-Han Lu Yung-Hui Huang Kuo-Ying Liu Tai-Been Chen |
| author_facet | Nan-Han Lu Yung-Hui Huang Kuo-Ying Liu Tai-Been Chen |
| author_sort | Nan-Han Lu |
| collection | DOAJ |
| description | Abstract This study aims to enhance the accuracy and efficiency of MRI-based brain tumor diagnosis by leveraging deep learning (DL) techniques applied to multichannel MRI inputs. MRI data were collected from 203 subjects, including 100 normal cases and 103 cases with 13 distinct brain tumor types. Non-contrast T1-weighted (T1w) and T2-weighted (T2w) images were combined with their average to form RGB three-channel inputs, enriching the representation for model training. Several convolutional neural network (CNN) architectures were evaluated for tumor classification, while fully convolutional networks (FCNs) were employed for tumor segmentation. Standard preprocessing, normalization, and training procedures were rigorously followed. The RGB fusion of T1w, T2w, and their average significantly enhanced model performance. The classification task achieved a top accuracy of 98.3% using the Darknet53 model, and segmentation attained a mean Dice score of 0.937 with ResNet50. These results demonstrate the effectiveness of multichannel input fusion and model selection in improving brain tumor analysis. While not yet integrated into clinical workflows, this approach holds promise for future development of DL-assisted decision-support tools in radiological practice. |
| format | Article |
| id | doaj-art-6b7a9e6ab1a14b3e96fcfd1c0ce153b1 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-6b7a9e6ab1a14b3e96fcfd1c0ce153b12025-08-20T03:42:52ZengNature PortfolioScientific Reports2045-23222025-07-0115112410.1038/s41598-025-13591-2Deep learning-driven brain tumor classification and segmentation using non-contrast MRINan-Han Lu0Yung-Hui Huang1Kuo-Ying Liu2Tai-Been Chen3Department of Radiology, E-DA Cancer Hospital, I-Shou UniversityDepartment of Medical Imaging and Radiological Science, I-Shou UniversityDepartment of Radiology, E-DA Cancer Hospital, I-Shou UniversityDepartment of Radiological Technology, Teikyo UniversityAbstract This study aims to enhance the accuracy and efficiency of MRI-based brain tumor diagnosis by leveraging deep learning (DL) techniques applied to multichannel MRI inputs. MRI data were collected from 203 subjects, including 100 normal cases and 103 cases with 13 distinct brain tumor types. Non-contrast T1-weighted (T1w) and T2-weighted (T2w) images were combined with their average to form RGB three-channel inputs, enriching the representation for model training. Several convolutional neural network (CNN) architectures were evaluated for tumor classification, while fully convolutional networks (FCNs) were employed for tumor segmentation. Standard preprocessing, normalization, and training procedures were rigorously followed. The RGB fusion of T1w, T2w, and their average significantly enhanced model performance. The classification task achieved a top accuracy of 98.3% using the Darknet53 model, and segmentation attained a mean Dice score of 0.937 with ResNet50. These results demonstrate the effectiveness of multichannel input fusion and model selection in improving brain tumor analysis. While not yet integrated into clinical workflows, this approach holds promise for future development of DL-assisted decision-support tools in radiological practice.https://doi.org/10.1038/s41598-025-13591-2Artificial intelligenceBrain MRIConvolutional neural networks (CNNs)Fully convolutional networks (FCNs)Deep learningTumor classification |
| spellingShingle | Nan-Han Lu Yung-Hui Huang Kuo-Ying Liu Tai-Been Chen Deep learning-driven brain tumor classification and segmentation using non-contrast MRI Scientific Reports Artificial intelligence Brain MRI Convolutional neural networks (CNNs) Fully convolutional networks (FCNs) Deep learning Tumor classification |
| title | Deep learning-driven brain tumor classification and segmentation using non-contrast MRI |
| title_full | Deep learning-driven brain tumor classification and segmentation using non-contrast MRI |
| title_fullStr | Deep learning-driven brain tumor classification and segmentation using non-contrast MRI |
| title_full_unstemmed | Deep learning-driven brain tumor classification and segmentation using non-contrast MRI |
| title_short | Deep learning-driven brain tumor classification and segmentation using non-contrast MRI |
| title_sort | deep learning driven brain tumor classification and segmentation using non contrast mri |
| topic | Artificial intelligence Brain MRI Convolutional neural networks (CNNs) Fully convolutional networks (FCNs) Deep learning Tumor classification |
| url | https://doi.org/10.1038/s41598-025-13591-2 |
| work_keys_str_mv | AT nanhanlu deeplearningdrivenbraintumorclassificationandsegmentationusingnoncontrastmri AT yunghuihuang deeplearningdrivenbraintumorclassificationandsegmentationusingnoncontrastmri AT kuoyingliu deeplearningdrivenbraintumorclassificationandsegmentationusingnoncontrastmri AT taibeenchen deeplearningdrivenbraintumorclassificationandsegmentationusingnoncontrastmri |