Effects of interleukin-12/23 inhibitors and interleukin-17 inhibitors on myocardial functions in patients with severe psoriasis
Background and Design: Systemic inflammation, which is involved in the pathogenesis of psoriasis, has been associated with the development of systemic diseases such as metabolic syndrome and cardiovascular disease. Without prospective data, the relationship between biological therapies and myocardia...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2024-12-01
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| Series: | Turkderm Turkish Archives of Dermatology and Venereology |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=turkderm&un=TURKDERM-20737 |
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| author | Leyla Baykal Selçuk Mursel Şahin Burcu Aydemir Deniz Aksu Arıca Savaş Yaylı |
| author_facet | Leyla Baykal Selçuk Mursel Şahin Burcu Aydemir Deniz Aksu Arıca Savaş Yaylı |
| author_sort | Leyla Baykal Selçuk |
| collection | DOAJ |
| description | Background and Design: Systemic inflammation, which is involved in the pathogenesis of psoriasis, has been associated with the development of systemic diseases such as metabolic syndrome and cardiovascular disease. Without prospective data, the relationship between biological therapies and myocardial function in patients with severe psoriasis remains unclear. This study aimed to evaluate myocardial function changes through various parameters in psoriasis patients undergoing biological therapy for 12 months.
Materials and Methods: Patients were evaluated at the beginning of treatment and after 12 months using transthoracic echocardiography to assess systolic and diastolic heart functions.
Results: A total of 39 patients (20 males, 19 females) with a mean age of 44.28+-13.54 years were included. All treatment groups significantly decreased psoriasis activity and severity index scores after 12 months (p<0.001). No significant changes in biochemical metabolic parameters were observed in any groups during the first year of treatment. A significant improvement in left ventricular global strain was observed in the ustekinumab, secukinumab, and ixekizumab groups compared to baseline (p<0.001, p=0.005, and p<0.001, respectively). A significant improvement in the E/e' ratio was noted in the ustekinumab and ixekizumab groups, but no change was found in the secukinumab group (p=0.017, p=0.010, and p=0.980, respectively).
Conclusion: This study observed improvements in systolic and diastolic cardiac functions in patients with severe psoriasis treated with antiinterleukin- 12/23 (IL-12/23) inhibitors and anti-IL-17 therapies. |
| format | Article |
| id | doaj-art-6b5e432f3aba42cca1d11d7b7c8785b5 |
| institution | Kabale University |
| issn | 2651-5164 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkderm Turkish Archives of Dermatology and Venereology |
| spelling | doaj-art-6b5e432f3aba42cca1d11d7b7c8785b52025-01-07T11:22:03ZengGalenos Publishing HouseTurkderm Turkish Archives of Dermatology and Venereology2651-51642024-12-0158411211610.4274/turkderm.galenos.2024.20737TURKDERM-20737Effects of interleukin-12/23 inhibitors and interleukin-17 inhibitors on myocardial functions in patients with severe psoriasisLeyla Baykal Selçuk0Mursel Şahin1Burcu Aydemir2Deniz Aksu Arıca3Savaş Yaylı4Karadeniz Technical University Faculty of Medicine, Department of Dermatology, Trabzon, TurkeyKaradeniz Technical University Faculty of Medicine, Department of Cardiology, Trabzon, TurkeyKaradeniz Technical University Faculty of Medicine, Department of Dermatology, Trabzon, TurkeyKaradeniz Technical University Faculty of Medicine, Department of Dermatology, Trabzon, TurkeyKoç University School of Medicine, Department of Dermatology, İstanbul, TürkiyeBackground and Design: Systemic inflammation, which is involved in the pathogenesis of psoriasis, has been associated with the development of systemic diseases such as metabolic syndrome and cardiovascular disease. Without prospective data, the relationship between biological therapies and myocardial function in patients with severe psoriasis remains unclear. This study aimed to evaluate myocardial function changes through various parameters in psoriasis patients undergoing biological therapy for 12 months. Materials and Methods: Patients were evaluated at the beginning of treatment and after 12 months using transthoracic echocardiography to assess systolic and diastolic heart functions. Results: A total of 39 patients (20 males, 19 females) with a mean age of 44.28+-13.54 years were included. All treatment groups significantly decreased psoriasis activity and severity index scores after 12 months (p<0.001). No significant changes in biochemical metabolic parameters were observed in any groups during the first year of treatment. A significant improvement in left ventricular global strain was observed in the ustekinumab, secukinumab, and ixekizumab groups compared to baseline (p<0.001, p=0.005, and p<0.001, respectively). A significant improvement in the E/e' ratio was noted in the ustekinumab and ixekizumab groups, but no change was found in the secukinumab group (p=0.017, p=0.010, and p=0.980, respectively). Conclusion: This study observed improvements in systolic and diastolic cardiac functions in patients with severe psoriasis treated with antiinterleukin- 12/23 (IL-12/23) inhibitors and anti-IL-17 therapies.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=turkderm&un=TURKDERM-20737psoriasisbiologicsmyocardial functions |
| spellingShingle | Leyla Baykal Selçuk Mursel Şahin Burcu Aydemir Deniz Aksu Arıca Savaş Yaylı Effects of interleukin-12/23 inhibitors and interleukin-17 inhibitors on myocardial functions in patients with severe psoriasis Turkderm Turkish Archives of Dermatology and Venereology psoriasis biologics myocardial functions |
| title | Effects of interleukin-12/23 inhibitors and interleukin-17 inhibitors on myocardial functions in patients with severe psoriasis |
| title_full | Effects of interleukin-12/23 inhibitors and interleukin-17 inhibitors on myocardial functions in patients with severe psoriasis |
| title_fullStr | Effects of interleukin-12/23 inhibitors and interleukin-17 inhibitors on myocardial functions in patients with severe psoriasis |
| title_full_unstemmed | Effects of interleukin-12/23 inhibitors and interleukin-17 inhibitors on myocardial functions in patients with severe psoriasis |
| title_short | Effects of interleukin-12/23 inhibitors and interleukin-17 inhibitors on myocardial functions in patients with severe psoriasis |
| title_sort | effects of interleukin 12 23 inhibitors and interleukin 17 inhibitors on myocardial functions in patients with severe psoriasis |
| topic | psoriasis biologics myocardial functions |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=turkderm&un=TURKDERM-20737 |
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