Phenylalanine modulates casein synthesis in bovine mammary epithelial cells by influencing amino acid transport and protein synthesis pathways

Phenylalanine modulates casein synthesis in bovine mammary epithelial cells by influencing amino acid transport and protein synthesis pathways

The efficiency of phenylalanine (Phe) utilization for milk protein synthesis in dairy cows is limited, and its uptake and metabolic mechanisms in the mammary tissue remaining unclear. This study investigated the effects of Phe availability (0.07, 0.14, 0.28, and 0.56 mM) on amino acid metabolism and...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yuanyuan Xing, Yixuan Luo, Mei Sun, Jing Yang, Shaoxiong Lin, Xiaojia Mu, Xiaoyu Niu, Dabiao Li, Yuanyuan Liu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Nutrition
Subjects:	phenylalanine amino acid transport amino acid metabolism bovine mammary epithelial cells casein synthesis mTOR signaling pathway
Online Access:	https://www.frontiersin.org/articles/10.3389/fnut.2025.1598191/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Aromatic Amino Acids: Phenylalanine and Tyrosine in Patients with Hypertension and Coronary Artery Disease
by: A. V. Krivova, et al.
Published: (2022-07-01)

Peri-operative protein or amino acid supplementation for total joint arthroplasty: a systematic review and meta-analysis
by: Yashar Khani, et al.
Published: (2025-05-01)

Rumen-protected methionine and lysine supplementation to the low protein diet improves animal growth through modulating colonic microbiome in lambs
by: Zhibin Luo, et al.
Published: (2025-03-01)

Design and synthesis of hydrophobic RGD-peptides derivatives
by: A. V. Dobrynina, et al.
Published: (2010-02-01)

Phenylalanine tolerance and neurological outcome of children with PKU in Egypt: a single center study
by: Aml Mahfouz, et al.
Published: (2025-12-01)

Methyl 3-[(tert-butoxycarbonyl)amino]benzoate
by: Murugesan Ponmagaram, et al.
Published: (2025-06-01)

Amino acids shape the metabolic and immunologic landscape in the tumor immune microenvironment: from molecular mechanisms to therapeutic strategies
by: Ziyou Lin, et al.
Published: (2025-07-01)

Synthesis of Amino-<i>gem</i>-Bisphosphonate Derivatives and Their Application as Synthons for the Preparation of Biorelevant Compounds
by: Mario Ordoñez, et al.
Published: (2025-07-01)

Amino acids and BCAA composition of Mungbean (Vigna radiata L.) seeds and sprouts for plant-based protein applications
by: Chanwook Kim, et al.
Published: (2025-08-01)

Preparation of high Fischer ratio peptides from seabuckthorn (Hippophae rhamnoides L.) seed meal, characterization and functional evaluation
by: Yuanju Zheng, et al.
Published: (2025-04-01)

JA‐Mediated Regulation of Amino Acid Homeostasis Adjusts Metabolic Flux and Enhances Spider Mite Tolerance via the SlJAZ8‐SlWRKY57‐SlAVT6s Module in Tomato
by: Yingchen Hao, et al.
Published: (2025-08-01)

Disturbances in amino acid metabolism in obstructive sleep apnea–hypopnea syndrome: insights from a cross-sectional study
by: Jiefeng Huang, et al.
Published: (2025-07-01)

Achieving reproductive performance and quality chicks with modern broiler breeders
by: Hugo Romero-Sanchez, et al.
Published: (2025-09-01)

d-Alanine content in the marine edible bivalve Panopea japonica and evaluation of its associated enzyme activities
by: Mayu Onozato, et al.
Published: (2025-07-01)

Nutritional contents of low phenylalanine diets: A mini review
by: A. S. M. Ammar
Published: (2023-10-01)

Insight into the structure of antitubercular Callyaerins: conformational studies and synthesis of a unique dehydroamino acid, β-aminodehydroalanine
by: Karolina Banaś, et al.
Published: (2025-08-01)

Plasma branched-chain amino acid concentrations in individuals without cardiovascular diseases versus patients diagnosed with hypertension and coronary artery disease
by: M. V. Kozhevnikova, et al.
Published: (2023-07-01)

Growth performance of male broiler chickens in different growth phases in response to amino acid concentrations in the pre-starter diet
by: Su Hyun An, et al.
Published: (2025-07-01)

L-Phenylalanine promotes liver steatosis by inhibiting BNIP3-mediated mitophagy
by: Ying Sun, et al.
Published: (2025-06-01)

Changes of physicochemical indexes and flavor substances of aged vinegar packaging with polyethylene blown film during storage period
by: KANG Shuaishuai, GAO Cuimei, WEI Ruteng, LI Qi, LI Yunlong, ZHANG Xiaoyu, XU Nv
Published: (2025-02-01)

Protein turnover, requirements, and how to use it according to the clinical situation in patients with parenteral nutrition
by: Adriana Flores-López, et al.
Published: (2025-07-01)

Effects of a high-protein corn coproduct as a replacement for soybean meal in calf starter feed in the postweaning period
by: R.G. Skinner, et al.
Published: (2025-06-01)

Design of 20-deoxyingenol-esters-based PKC agonists and their lysosome biogenesis-enhancing activity
by: Jia-Jia Wan, et al.
Published: (2025-06-01)

Characteristics of Amino Acid and Glucose Digestion and Metabolism in Energy and Protein Feedstuffs for Pigs
by: Jiayu Tu, et al.
Published: (2025-05-01)

Protein Quality Assessment of the Deoiled Guamuchil (Pithecellobium dulce [Roxb.]) Seed Flour
by: Nitzia Thalía Flores‐Jiménez, et al.
Published: (2025-03-01)

Serum Microelements, Amino Acids and Acyl Carnitines Levels in Pregnancies Complicated with Preeclampsia: A Prospective Study
by: Min Zhang, et al.
Published: (2022-05-01)

Gut Microbiota Contribute to Heterosis for Growth Trait and Muscle Nutrient Composition in Hybrid Largemouth Bass (<i>Micropterus salmoides</i>)
by: Jixiang Hua, et al.
Published: (2025-06-01)

Effect of graded levels of fiber from alfalfa meal on apparent and standardized ileal digestibility of amino acids of growing pigs
by: Liang CHEN, et al.
Published: (2015-12-01)

Effects of supplementing tributyrin on serum biochemical indices and meat quality characteristics of longissimus thoracis et lumborum of weaned Small-Tailed Han lambs
by: Ya-Xin Wang, et al.
Published: (2024-01-01)

Synthesis of two isomers of 3-amino-7α-12α-dihydroxy-5β-cholanic acid
by: D. O. Barsuk, et al.
Published: (2015-04-01)

Effect of Ammonium:Nitrate Application Ratios on Growth and Nitrogen Metabolism of Tea Plants (Camellia sinensis L.)
by: Takuo Enomoto, et al.
Published: (2025-06-01)

Comparison of methodologies to determine the apparent ileal amino acid digestibility of maize, wheat, lupins, and peas for broiler chickens
by: C.L. Nalle, et al.
Published: (2021-08-01)

Optimizing Apparent Metabolizable Energy and Digestible Amino Acids of Layer Feed by Response Surface Methodology
by: H. Widjaja, et al.
Published: (2025-05-01)

Phytohormone and Amino Acid Changes in Cherry Radish as Metabolic Adaptive Response to Arsenic Single and Multi-Contamination
by: Daniela Pavlíková, et al.
Published: (2025-03-01)

Amino acid neurotransmitters in sarcopenia and healthy aging
by: Steffi M. Jonk, et al.
Published: (2025-09-01)

Application of the three compartment model to study of amino acid digestibility in small intestine of goat
by: GUO Chun-hua, et al.
Published: (2005-11-01)

The synthesis diagnostic test systems on the basis of polymer microspheres in the presence of polyvinylpyrrolidone modified with an amino acid
by: Z. B. Artykova, et al.
Published: (2010-06-01)

Long term chlorantraniliprole exposure induced intestinal and cognitive impairment via inducing lipid and amino acid metabolism dysfunction
by: Xin-Yu Wang, et al.
Published: (2025-07-01)

Correlation between changes of amino acid spectrum and alopecia in patients with obesity undergoing bariatric surgery: a prospective cohort study
by: Tingwen Wang, et al.
Published: (2025-08-01)

Intraperitoneal injection but not oral administration of ellagic acid: a novel immunomodulator via targeting casein kinase 2 signaling pathway
by: Wenhui Qi, et al.
Published: (2025-07-01)