Arginase-II promotes melanoma and lung cancer cell growth by regulating Sirt3-mtROS axis

Arginase-II promotes melanoma and lung cancer cell growth by regulating Sirt3-mtROS axis

BackgroundAberrant mitochondrial metabolism is a key source of massive mitochondrial reactive oxygen species (mtROS) in tumour cells. Arginase-II (Arg-II), a widely expressed mitochondrial metabolic enzyme, has recently been shown to enhance mtROS production and melanoma progression. However, how Ar...

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Bibliographic Details
Main Authors: Yang Yang, Andrea Brenna, Duilio M. Potenza, Santhoshkumar Sundaramoorthy, Xin Cheng, Xiu-Fen Ming, Zhihong Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
arginase-II
DNA damage
melanoma
mtROS
nuclear deformation
sirt3
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1528972/full
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