Deriving a Health-Based Guidance Value for 9,10-Anthraquinone via integrating PBTK modeling-based reverse dosimetry and In Vitro bioassays

Deriving a Health-Based Guidance Value for 9,10-Anthraquinone via integrating PBTK modeling-based reverse dosimetry and In Vitro bioassays

Anthraquinones, both naturally occurring and synthetic, are widely distributed in the environment. Recent years, human exposure to 9,10-anthraquinone (9,10-AQ) through contaminated food has been raising significant health concerns due to its potential toxicity upon chronic exposure. Among these, 9,1...

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Main Authors: Da Zhang, Miaoying Shi, Junyu Ning, Shan Zheng, Yi Yang, Xudong Jia, Yaru Tian, Zinan Li, Nan Zhang, Ying Feng, Shan Gao, Zhuangsheng Tan, Jau-Shyong Hong, Ru-Band Lu, Jiaxue Wang, Haiming Jing, Guojun Li
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Environment International
Subjects:
9,10-anthraquinone (9,10-AQ)
Physiologically based toxicokinetic (PBTK) model
Quantitative in vitro to in vivo extrapolation (QIVIVE)
Benchmark dose (BMD)
Health-based guidance value (HBGV)
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412025003058
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