The effect of probiotics, prebiotics and synbiotics on gut microbial community profile in overweight and obese Latin American and Caribbean populations: a systematic review of human trials
Oral supplementation with probiotics, prebiotics, and synbiotics is a novel potential complementary therapy for addressing overweight and obesity through gut microbiota modulation. This systematic review provides a comprehensive summary of the existing evidence to guide future research. Literature s...
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| Format: | Article |
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Cambridge University Press
2025-01-01
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| Series: | Gut Microbiome |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2632289724000124/type/journal_article |
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| author | Manahil M. Bineid Litai Liu Eduard F. Ventura Sakshi Bansal Katherine Curi-Quinto Juana del Valle-Mendoza Gemma E. Walton Karani Santhanakrishnan Vimaleswaran |
| author_facet | Manahil M. Bineid Litai Liu Eduard F. Ventura Sakshi Bansal Katherine Curi-Quinto Juana del Valle-Mendoza Gemma E. Walton Karani Santhanakrishnan Vimaleswaran |
| author_sort | Manahil M. Bineid |
| collection | DOAJ |
| description | Oral supplementation with probiotics, prebiotics, and synbiotics is a novel potential complementary therapy for addressing overweight and obesity through gut microbiota modulation. This systematic review provides a comprehensive summary of the existing evidence to guide future research. Literature searches were conducted in four databases to identify human trials published until May 2024 that examined the impact of probiotic, prebiotic, or synbiotic interventions on faecal microbiota composition changes in overweight and obese participants from Latin American and Caribbean populations (LACPs). Of the 13,090 identified records, five randomised controlled trials (RCTs) from Brazil, Mexico, and Chile met the inclusion criteria for this review. The included RCTs evaluated different forms of therapies over short-term interventions (6 or 8 weeks), with sample sizes ranging from 21 to 39 participants across the studies. Variations in the reported outcomes were observed due to differences in supplement formulation, dosage, population characteristics, and methodological heterogeneity. The findings indicate that the available data are inadequate to establish definitive conclusions regarding the impact of biotic treatments on gut microbiota profiles in LACP. Further research with larger sample sizes and precise microbiota analysis is required to elucidate the implications of dietary interventions on gut microbiota in obesity and related disorders. |
| format | Article |
| id | doaj-art-6b18a3b8c9fe4d34a1ed6d027012b1e8 |
| institution | Kabale University |
| issn | 2632-2897 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Gut Microbiome |
| spelling | doaj-art-6b18a3b8c9fe4d34a1ed6d027012b1e82025-01-17T08:46:43ZengCambridge University PressGut Microbiome2632-28972025-01-01610.1017/gmb.2024.12The effect of probiotics, prebiotics and synbiotics on gut microbial community profile in overweight and obese Latin American and Caribbean populations: a systematic review of human trialsManahil M. Bineid0Litai Liu1Eduard F. Ventura2Sakshi Bansal3Katherine Curi-Quinto4Juana del Valle-Mendoza5Gemma E. Walton6https://orcid.org/0000-0001-5426-5635Karani Santhanakrishnan Vimaleswaran7https://orcid.org/0000-0002-8485-8930Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading,UKHugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading,UKDepartment of Biotechnology, Institute of Agrochemistry and Food Technology, Spanish National Research Council (IATA-CSIC), Valencia, SpainHugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading,UKInstituto de Investigación Nutricional, Lima, Peru Escuela de Nutrición de la Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima, PeruInstituto de Investigación Nutricional, Lima, Peru Escuela de Medicina, Centro de Investigación e Innovación de la Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima, PeruFood Microbial Sciences Unit, Department of Food and Nutritional Sciences, University of Reading, Whiteknights, Reading, UKHugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading,UK The Institute for Food, Nutrition, and Health (IFNH), University of Reading, Reading, UKOral supplementation with probiotics, prebiotics, and synbiotics is a novel potential complementary therapy for addressing overweight and obesity through gut microbiota modulation. This systematic review provides a comprehensive summary of the existing evidence to guide future research. Literature searches were conducted in four databases to identify human trials published until May 2024 that examined the impact of probiotic, prebiotic, or synbiotic interventions on faecal microbiota composition changes in overweight and obese participants from Latin American and Caribbean populations (LACPs). Of the 13,090 identified records, five randomised controlled trials (RCTs) from Brazil, Mexico, and Chile met the inclusion criteria for this review. The included RCTs evaluated different forms of therapies over short-term interventions (6 or 8 weeks), with sample sizes ranging from 21 to 39 participants across the studies. Variations in the reported outcomes were observed due to differences in supplement formulation, dosage, population characteristics, and methodological heterogeneity. The findings indicate that the available data are inadequate to establish definitive conclusions regarding the impact of biotic treatments on gut microbiota profiles in LACP. Further research with larger sample sizes and precise microbiota analysis is required to elucidate the implications of dietary interventions on gut microbiota in obesity and related disorders.https://www.cambridge.org/core/product/identifier/S2632289724000124/type/journal_articleprobioticsprebioticssynbioticsgut microbiotaobesityLACP |
| spellingShingle | Manahil M. Bineid Litai Liu Eduard F. Ventura Sakshi Bansal Katherine Curi-Quinto Juana del Valle-Mendoza Gemma E. Walton Karani Santhanakrishnan Vimaleswaran The effect of probiotics, prebiotics and synbiotics on gut microbial community profile in overweight and obese Latin American and Caribbean populations: a systematic review of human trials Gut Microbiome probiotics prebiotics synbiotics gut microbiota obesity LACP |
| title | The effect of probiotics, prebiotics and synbiotics on gut microbial community profile in overweight and obese Latin American and Caribbean populations: a systematic review of human trials |
| title_full | The effect of probiotics, prebiotics and synbiotics on gut microbial community profile in overweight and obese Latin American and Caribbean populations: a systematic review of human trials |
| title_fullStr | The effect of probiotics, prebiotics and synbiotics on gut microbial community profile in overweight and obese Latin American and Caribbean populations: a systematic review of human trials |
| title_full_unstemmed | The effect of probiotics, prebiotics and synbiotics on gut microbial community profile in overweight and obese Latin American and Caribbean populations: a systematic review of human trials |
| title_short | The effect of probiotics, prebiotics and synbiotics on gut microbial community profile in overweight and obese Latin American and Caribbean populations: a systematic review of human trials |
| title_sort | effect of probiotics prebiotics and synbiotics on gut microbial community profile in overweight and obese latin american and caribbean populations a systematic review of human trials |
| topic | probiotics prebiotics synbiotics gut microbiota obesity LACP |
| url | https://www.cambridge.org/core/product/identifier/S2632289724000124/type/journal_article |
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