The Dose Rate of Corpuscular Ionizing Radiation Strongly Influences the Severity of DNA Damage, Cell Cycle Progression and Cellular Senescence in Human Epidermoid Carcinoma Cells

The Dose Rate of Corpuscular Ionizing Radiation Strongly Influences the Severity of DNA Damage, Cell Cycle Progression and Cellular Senescence in Human Epidermoid Carcinoma Cells

Modern radiotherapy utilizes a broad range of sources of ionizing radiation, both low-dose-rate (LDR) and high-dose-rate (HDR). However, the mechanisms underlying specific dose-rate effects remain unclear, especially for corpuscular radiation. To address this issue, we have irradiated human epidermo...

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Main Authors: Sergey S. Soroko, Dmitry V. Skamnitskiy, Ekaterina N. Gorshkova, Olga M. Kutova, Ismail R. Seriev, Anna V. Maslennikova, Evgeniy L. Guryev, Sergey V. Gudkov, Vladimir A. Vodeneev, Irina V. Balalaeva, Natalia Yu Shilyagina
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Current Issues in Molecular Biology
Subjects:
ionizing radiation
radiotherapy
cancer
low dose rate
high dose rate
mechanism cell response
Online Access:https://www.mdpi.com/1467-3045/46/12/828
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