Manipulating dietary protein and amino acids in the common marmoset Callithrix jacchus impacts circulating metabolites and FGF21 levels
Abstract Restricting dietary protein intake has metabolic and physiological benefits for animals. Rodent studies have identified the involvement of a hormone, fibroblast growth factor 21 (FGF21), which is upregulated by sensing amino acid scarcity. However, to what extent this mechanism is conserved...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-16749-0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849226356217348096 |
|---|---|
| author | Yuka Fujita Tomoko Ishibuchi Akiko Uematsu Takuya Hayashi Fumiaki Obata |
| author_facet | Yuka Fujita Tomoko Ishibuchi Akiko Uematsu Takuya Hayashi Fumiaki Obata |
| author_sort | Yuka Fujita |
| collection | DOAJ |
| description | Abstract Restricting dietary protein intake has metabolic and physiological benefits for animals. Rodent studies have identified the involvement of a hormone, fibroblast growth factor 21 (FGF21), which is upregulated by sensing amino acid scarcity. However, to what extent this mechanism is conserved in primates remains elusive. Using common marmosets, Callithrix jacchus, as a non-human primate model, we develop a protocol for protein restriction and dietary amino acid manipulation. Low protein diet induces a decrease in blood urea nitrogen, altered plasma amino acid profiles, and an increase in plasma FGF21. Supplementation of purified amino acids to the diet suppresses plasma features of protein restriction. Our study provides a dietary intervention technique in marmosets and an insight into the evolutionarily conserved mechanism of FGF21 induction during protein restriction. |
| format | Article |
| id | doaj-art-6ae70bb4a5fd42e0818ec3a25a781d0c |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-6ae70bb4a5fd42e0818ec3a25a781d0c2025-08-24T11:22:55ZengNature PortfolioScientific Reports2045-23222025-08-0115111210.1038/s41598-025-16749-0Manipulating dietary protein and amino acids in the common marmoset Callithrix jacchus impacts circulating metabolites and FGF21 levelsYuka Fujita0Tomoko Ishibuchi1Akiko Uematsu2Takuya Hayashi3Fumiaki Obata4Laboratory for Nutritional Biology, RIKEN Center for Biosystems Dynamics ResearchLaboratory for Brain Connectomics Imaging, RIKEN Center for Biosystems Dynamics ResearchLaboratory for Brain Connectomics Imaging, RIKEN Center for Biosystems Dynamics ResearchLaboratory for Brain Connectomics Imaging, RIKEN Center for Biosystems Dynamics ResearchLaboratory for Nutritional Biology, RIKEN Center for Biosystems Dynamics ResearchAbstract Restricting dietary protein intake has metabolic and physiological benefits for animals. Rodent studies have identified the involvement of a hormone, fibroblast growth factor 21 (FGF21), which is upregulated by sensing amino acid scarcity. However, to what extent this mechanism is conserved in primates remains elusive. Using common marmosets, Callithrix jacchus, as a non-human primate model, we develop a protocol for protein restriction and dietary amino acid manipulation. Low protein diet induces a decrease in blood urea nitrogen, altered plasma amino acid profiles, and an increase in plasma FGF21. Supplementation of purified amino acids to the diet suppresses plasma features of protein restriction. Our study provides a dietary intervention technique in marmosets and an insight into the evolutionarily conserved mechanism of FGF21 induction during protein restriction.https://doi.org/10.1038/s41598-025-16749-0Protein restrictionMarmosetAmino acidsFGF21 |
| spellingShingle | Yuka Fujita Tomoko Ishibuchi Akiko Uematsu Takuya Hayashi Fumiaki Obata Manipulating dietary protein and amino acids in the common marmoset Callithrix jacchus impacts circulating metabolites and FGF21 levels Scientific Reports Protein restriction Marmoset Amino acids FGF21 |
| title | Manipulating dietary protein and amino acids in the common marmoset Callithrix jacchus impacts circulating metabolites and FGF21 levels |
| title_full | Manipulating dietary protein and amino acids in the common marmoset Callithrix jacchus impacts circulating metabolites and FGF21 levels |
| title_fullStr | Manipulating dietary protein and amino acids in the common marmoset Callithrix jacchus impacts circulating metabolites and FGF21 levels |
| title_full_unstemmed | Manipulating dietary protein and amino acids in the common marmoset Callithrix jacchus impacts circulating metabolites and FGF21 levels |
| title_short | Manipulating dietary protein and amino acids in the common marmoset Callithrix jacchus impacts circulating metabolites and FGF21 levels |
| title_sort | manipulating dietary protein and amino acids in the common marmoset callithrix jacchus impacts circulating metabolites and fgf21 levels |
| topic | Protein restriction Marmoset Amino acids FGF21 |
| url | https://doi.org/10.1038/s41598-025-16749-0 |
| work_keys_str_mv | AT yukafujita manipulatingdietaryproteinandaminoacidsinthecommonmarmosetcallithrixjacchusimpactscirculatingmetabolitesandfgf21levels AT tomokoishibuchi manipulatingdietaryproteinandaminoacidsinthecommonmarmosetcallithrixjacchusimpactscirculatingmetabolitesandfgf21levels AT akikouematsu manipulatingdietaryproteinandaminoacidsinthecommonmarmosetcallithrixjacchusimpactscirculatingmetabolitesandfgf21levels AT takuyahayashi manipulatingdietaryproteinandaminoacidsinthecommonmarmosetcallithrixjacchusimpactscirculatingmetabolitesandfgf21levels AT fumiakiobata manipulatingdietaryproteinandaminoacidsinthecommonmarmosetcallithrixjacchusimpactscirculatingmetabolitesandfgf21levels |