Enhanced production of extracellular L-asparaginase in batch culture via nitrous acid-induced mutagenesis of Aspergillus oryzae

Enhanced production of extracellular L-asparaginase in batch culture via nitrous acid-induced mutagenesis of Aspergillus oryzae

Abstract Background L-Asparaginase (LA) is an important enzyme with therapeutic and industrial applications, particularly in the treatment of leukemia. Enhancing its production through optimization and strain improvement is crucial for commercial viability. This study aimed to increase LA production...

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Bibliographic Details
Main Authors: Sikander Ali, Sana Maqsood, Muhammad Usman Ahmad, Ifrah Shabbir, Mohammad Raish, Fozia Batool, Asad-ur-Rehman, Iram Liaqat, Bakar Bin Khatab Abbasi, Ali Irfan, Yousef A. Bin Jardan
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Microbial Cell Factories
Subjects:
L-asparaginase
Aspergillus oryzae
Solid-state fermentation
Chemical mutagenesis
Enzyme optimization
Sugarcane bagasse
Online Access:https://doi.org/10.1186/s12934-025-02797-8
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