Role and Application of Intravenous High-Dose Vitamin C in Cancer
An increasing number of evidence indicate that intravenous high-dose vitamin C (HVC) is safe to use in patients with various types of cancer. Clinical studies suggest that when used in combination with radiation and chemotherapy, HVC can reduce their toxic side effects and substantially prolong the...
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Magazine House of Cancer Research on Prevention and Treatment
2024-11-01
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| Series: | Zhongliu Fangzhi Yanjiu |
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| Online Access: | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2024.24.0514 |
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| author | Junwen OU |
| author_facet | Junwen OU |
| author_sort | Junwen OU |
| collection | DOAJ |
| description | An increasing number of evidence indicate that intravenous high-dose vitamin C (HVC) is safe to use in patients with various types of cancer. Clinical studies suggest that when used in combination with radiation and chemotherapy, HVC can reduce their toxic side effects and substantially prolong the overall survival of patients. In vitro and animal experiments demonstrated that vitamin C has pro-oxidant cytotoxicity, reverses epithelial-mesenchymal transition, inhibits hypoxia and oncogenic kinase signal transduction, and improves immune function. Although many phase Ⅰ/Ⅱ clinical studies and case reports confirming the adjuvant anti-tumor effects of HVC have been published, large-sample, multicenter randomized controlled phase Ⅲ clinical trial data are still lacking. Therefore, this paper further explores the role and significance of this low-toxicity adjuvant antitumor therapy in clinical use. |
| format | Article |
| id | doaj-art-6ac8b6a43a91456aa6d64b4f1b201247 |
| institution | Kabale University |
| issn | 1000-8578 |
| language | zho |
| publishDate | 2024-11-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj-art-6ac8b6a43a91456aa6d64b4f1b2012472024-11-28T06:27:56ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782024-11-01511189289710.3971/j.issn.1000-8578.2024.24.051420240514Role and Application of Intravenous High-Dose Vitamin C in CancerJunwen OU0Clifford Hospital International Health Management Center, Guangzhou 511495, ChinaAn increasing number of evidence indicate that intravenous high-dose vitamin C (HVC) is safe to use in patients with various types of cancer. Clinical studies suggest that when used in combination with radiation and chemotherapy, HVC can reduce their toxic side effects and substantially prolong the overall survival of patients. In vitro and animal experiments demonstrated that vitamin C has pro-oxidant cytotoxicity, reverses epithelial-mesenchymal transition, inhibits hypoxia and oncogenic kinase signal transduction, and improves immune function. Although many phase Ⅰ/Ⅱ clinical studies and case reports confirming the adjuvant anti-tumor effects of HVC have been published, large-sample, multicenter randomized controlled phase Ⅲ clinical trial data are still lacking. Therefore, this paper further explores the role and significance of this low-toxicity adjuvant antitumor therapy in clinical use.http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2024.24.0514intravenoushigh-dose vitamin ccancermechanismbiomarker |
| spellingShingle | Junwen OU Role and Application of Intravenous High-Dose Vitamin C in Cancer Zhongliu Fangzhi Yanjiu intravenous high-dose vitamin c cancer mechanism biomarker |
| title | Role and Application of Intravenous High-Dose Vitamin C in Cancer |
| title_full | Role and Application of Intravenous High-Dose Vitamin C in Cancer |
| title_fullStr | Role and Application of Intravenous High-Dose Vitamin C in Cancer |
| title_full_unstemmed | Role and Application of Intravenous High-Dose Vitamin C in Cancer |
| title_short | Role and Application of Intravenous High-Dose Vitamin C in Cancer |
| title_sort | role and application of intravenous high dose vitamin c in cancer |
| topic | intravenous high-dose vitamin c cancer mechanism biomarker |
| url | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2024.24.0514 |
| work_keys_str_mv | AT junwenou roleandapplicationofintravenoushighdosevitamincincancer |