Roles of supporting cells in the maintenance and regeneration of the damaged inner ear: A literature review
The inner ear sensory epithelium consists of two major types of cells: hair cells (HCs) and supporting cells (SCs). Critical functions of HCs in the perception of mechanical stimulation and mechanosensory transduction have long been elucidated. SCs are indispensable components of the sensory epithel...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-10-01
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| Series: | Journal of Otology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1672293024000369 |
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| author | Jing-Ying Guo Jun-Yi Xu Shu-Sheng Gong Guo-Peng Wang |
| author_facet | Jing-Ying Guo Jun-Yi Xu Shu-Sheng Gong Guo-Peng Wang |
| author_sort | Jing-Ying Guo |
| collection | DOAJ |
| description | The inner ear sensory epithelium consists of two major types of cells: hair cells (HCs) and supporting cells (SCs). Critical functions of HCs in the perception of mechanical stimulation and mechanosensory transduction have long been elucidated. SCs are indispensable components of the sensory epithelia, and they maintain the structural integrity and ionic environment of the inner ear. Once delicate inner ear epithelia sustain injuries (for example, due to ototoxic drugs or noise exposure), SCs respond immediately to serve as repairers of the epithelium and as adapters to become HC progenitors, aiming at morphological and functional recovery of the inner ear. This regenerative process is extensive in non-mammals, but is limited in the mammalian inner ear, especially in the mature cochlea. This review aimed to discuss the important roles of SCs in the repair of the mammalian inner ear. |
| format | Article |
| id | doaj-art-6ac4da49daff4efeadda0dfcbdbb3bd4 |
| institution | Kabale University |
| issn | 1672-2930 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Otology |
| spelling | doaj-art-6ac4da49daff4efeadda0dfcbdbb3bd42024-12-11T05:55:51ZengElsevierJournal of Otology1672-29302024-10-01194234240Roles of supporting cells in the maintenance and regeneration of the damaged inner ear: A literature reviewJing-Ying Guo0Jun-Yi Xu1Shu-Sheng Gong2Guo-Peng Wang3Department of Otolaryngology-Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China; Clinical Center for Hearing Loss, Capital Medical University, Beijing, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China; Clinical Center for Hearing Loss, Capital Medical University, Beijing, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China; Clinical Center for Hearing Loss, Capital Medical University, Beijing, China; Corresponding author. Department of Otolaryngology-Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, 95th Yong'an Road, Xicheng District, Beijing, 100050, China.Department of Otolaryngology-Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China; Clinical Center for Hearing Loss, Capital Medical University, Beijing, China; Corresponding author. Department of Otolaryngology-Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, 95th Yong'an Road, Xicheng District, Beijing, 100050, China.The inner ear sensory epithelium consists of two major types of cells: hair cells (HCs) and supporting cells (SCs). Critical functions of HCs in the perception of mechanical stimulation and mechanosensory transduction have long been elucidated. SCs are indispensable components of the sensory epithelia, and they maintain the structural integrity and ionic environment of the inner ear. Once delicate inner ear epithelia sustain injuries (for example, due to ototoxic drugs or noise exposure), SCs respond immediately to serve as repairers of the epithelium and as adapters to become HC progenitors, aiming at morphological and functional recovery of the inner ear. This regenerative process is extensive in non-mammals, but is limited in the mammalian inner ear, especially in the mature cochlea. This review aimed to discuss the important roles of SCs in the repair of the mammalian inner ear.http://www.sciencedirect.com/science/article/pii/S1672293024000369 |
| spellingShingle | Jing-Ying Guo Jun-Yi Xu Shu-Sheng Gong Guo-Peng Wang Roles of supporting cells in the maintenance and regeneration of the damaged inner ear: A literature review Journal of Otology |
| title | Roles of supporting cells in the maintenance and regeneration of the damaged inner ear: A literature review |
| title_full | Roles of supporting cells in the maintenance and regeneration of the damaged inner ear: A literature review |
| title_fullStr | Roles of supporting cells in the maintenance and regeneration of the damaged inner ear: A literature review |
| title_full_unstemmed | Roles of supporting cells in the maintenance and regeneration of the damaged inner ear: A literature review |
| title_short | Roles of supporting cells in the maintenance and regeneration of the damaged inner ear: A literature review |
| title_sort | roles of supporting cells in the maintenance and regeneration of the damaged inner ear a literature review |
| url | http://www.sciencedirect.com/science/article/pii/S1672293024000369 |
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