Risk factors for all-cause mortality during the COVID-19 pandemic compared with the pre-pandemic period in an adult population of Arkhangelsk, Russia
Abstract We investigated and compared mortality rates and risk factors for pre-pandemic and pandemic all-cause mortality in a population-based cohort of men and women in Arkhangelsk, Russia. A prospective cohort study enrolled 2,324 participants aged 35 to 69 years between 2015 and 2017. All partici...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-85360-0 |
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| author | Ekaterina Krieger Alexander V. Kudryavtsev Ekaterina Sharashova Olga Samodova Vitaly A. Postoev |
| author_facet | Ekaterina Krieger Alexander V. Kudryavtsev Ekaterina Sharashova Olga Samodova Vitaly A. Postoev |
| author_sort | Ekaterina Krieger |
| collection | DOAJ |
| description | Abstract We investigated and compared mortality rates and risk factors for pre-pandemic and pandemic all-cause mortality in a population-based cohort of men and women in Arkhangelsk, Russia. A prospective cohort study enrolled 2,324 participants aged 35 to 69 years between 2015 and 2017. All participants were followed up for all-cause deaths using the mortality registry. Mortality rates per 1000 person-years were calculated for men and women in the pre-pandemic and pandemic periods. Cox regression models were used to investigate demographic, lifestyle, and health characteristics associated with increased risk of death in both periods. During the pandemic, age-standardized all-cause mortality increased in women, but minor change was observed in men. Older age, smoking, and diabetes were associated with a higher risk of all-cause death in both periods and for both sexes. In women, higher risk during the pandemic was associated with obesity, angina, elevated cystatin C levels, and a history of COVID-19. In men, asthma and elevated hs-Troponin T levels increased the risk of death during the pandemic, while elevated hs-CRP and NT-proBNP levels were associated with higher risk in both periods. Targeted preventive interventions for men and women with specific risk factors can be implemented during potential future infectious disease outbreaks. |
| format | Article |
| id | doaj-art-6ab5fac25049406496ae3052f81ab90e |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-6ab5fac25049406496ae3052f81ab90e2025-01-12T12:21:55ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-025-85360-0Risk factors for all-cause mortality during the COVID-19 pandemic compared with the pre-pandemic period in an adult population of Arkhangelsk, RussiaEkaterina Krieger0Alexander V. Kudryavtsev1Ekaterina Sharashova2Olga Samodova3Vitaly A. Postoev4Department of Community Medicine, UiT The Arctic University of NorwayInternational Research Competence Centre, Northern State Medical UniversityDepartment of Community Medicine, UiT The Arctic University of NorwayDepartment of Infectious Diseases, Northern State Medical UniversityDepartment of Research Methodology, Northern State Medical UniversityAbstract We investigated and compared mortality rates and risk factors for pre-pandemic and pandemic all-cause mortality in a population-based cohort of men and women in Arkhangelsk, Russia. A prospective cohort study enrolled 2,324 participants aged 35 to 69 years between 2015 and 2017. All participants were followed up for all-cause deaths using the mortality registry. Mortality rates per 1000 person-years were calculated for men and women in the pre-pandemic and pandemic periods. Cox regression models were used to investigate demographic, lifestyle, and health characteristics associated with increased risk of death in both periods. During the pandemic, age-standardized all-cause mortality increased in women, but minor change was observed in men. Older age, smoking, and diabetes were associated with a higher risk of all-cause death in both periods and for both sexes. In women, higher risk during the pandemic was associated with obesity, angina, elevated cystatin C levels, and a history of COVID-19. In men, asthma and elevated hs-Troponin T levels increased the risk of death during the pandemic, while elevated hs-CRP and NT-proBNP levels were associated with higher risk in both periods. Targeted preventive interventions for men and women with specific risk factors can be implemented during potential future infectious disease outbreaks.https://doi.org/10.1038/s41598-025-85360-0COVID-19SARS-CoV-2All-cause mortalityRisk factorsRussia |
| spellingShingle | Ekaterina Krieger Alexander V. Kudryavtsev Ekaterina Sharashova Olga Samodova Vitaly A. Postoev Risk factors for all-cause mortality during the COVID-19 pandemic compared with the pre-pandemic period in an adult population of Arkhangelsk, Russia Scientific Reports COVID-19 SARS-CoV-2 All-cause mortality Risk factors Russia |
| title | Risk factors for all-cause mortality during the COVID-19 pandemic compared with the pre-pandemic period in an adult population of Arkhangelsk, Russia |
| title_full | Risk factors for all-cause mortality during the COVID-19 pandemic compared with the pre-pandemic period in an adult population of Arkhangelsk, Russia |
| title_fullStr | Risk factors for all-cause mortality during the COVID-19 pandemic compared with the pre-pandemic period in an adult population of Arkhangelsk, Russia |
| title_full_unstemmed | Risk factors for all-cause mortality during the COVID-19 pandemic compared with the pre-pandemic period in an adult population of Arkhangelsk, Russia |
| title_short | Risk factors for all-cause mortality during the COVID-19 pandemic compared with the pre-pandemic period in an adult population of Arkhangelsk, Russia |
| title_sort | risk factors for all cause mortality during the covid 19 pandemic compared with the pre pandemic period in an adult population of arkhangelsk russia |
| topic | COVID-19 SARS-CoV-2 All-cause mortality Risk factors Russia |
| url | https://doi.org/10.1038/s41598-025-85360-0 |
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