Characterising developmental dynamics of adult epigenetic clock sitesResearch in context

Characterising developmental dynamics of adult epigenetic clock sitesResearch in context

Summary: Background: DNA methylation (DNAm), an epigenetic mechanism that regulates gene activity in response to genetic and environmental influences, changes as we age. DNAm at specific sites on the genome can be used to calculate ‘epigenetic clocks’, which are powerful biomarkers of age, as well...

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Bibliographic Details
Main Authors: Rosa H. Mulder, Alexander Neumann, Janine F. Felix, Matthew Suderman, Charlotte A.M. Cecil
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:EBioMedicine
Subjects:
Epigenetic clocks
DNA methylation
Development
Early origins
The generation R study
ALSPAC
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424004614
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