Effect of benralizumab on inflammation in skin after intradermal allergen challenge in patients with moderate-to-severe atopic dermatitis

Effect of benralizumab on inflammation in skin after intradermal allergen challenge in patients with moderate-to-severe atopic dermatitis

Background: Atopic dermatitis (AD) is a skin barrier dysfunction characterized by tissue eosinophilia. Objective: In patients with AD, we evaluated the effect of eosinophil depletion with benralizumab on markers of inflammation in skin after intradermal allergen challenge. Methods: A total of 20 pat...

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Main Authors: Christiane E. Whetstone, BSc, Ruth P. Cusack, MB, MPH, Emma Price, MSc, Karen Howie, Catie Stevens, BSc, Dhuha Al-Sajee, MD, PhD, Sue Beaudin, BSc, Jennifer Wattie, Nadia Alsaji, MBChB, Abbey Schlatman, BSc, Vanessa Luk, BHSc, Xiaotian Ju, PhD, Paul O’Byrne, MB, Mark Inman, MD, PhD, Roma Sehmi, PhD, Hermenio Lima, MD, PhD, Gail M. Gauvreau, PhD
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Journal of Allergy and Clinical Immunology: Global
Subjects:
Atopic dermatitis
benralizumab
eosinophil
CD125
intradermal allergen challenge
Online Access:http://www.sciencedirect.com/science/article/pii/S2772829324001061
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