An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway
Nuclear factor-κB (NF-κB) cell signaling pathway is essential for the progression and development of numerous human disorders, including cancer. NF-κB signaling pathway regulates a wide range of physiological processes, such as cell survival, growth, and migration. Deregulated NF-kB signaling result...
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| Format: | Article |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1513422/full |
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| author | Pratibha Pandey Sorabh Lakhanpal Danish Mahmood Han Na Kang Byunggyu Kim Sojin Kang Jinwon Choi Min Choi Shivam Pandey Mahakshit Bhat Shilpa Sharma Fahad Khan Moon Nyeo Park Bonglee Kim Bonglee Kim |
| author_facet | Pratibha Pandey Sorabh Lakhanpal Danish Mahmood Han Na Kang Byunggyu Kim Sojin Kang Jinwon Choi Min Choi Shivam Pandey Mahakshit Bhat Shilpa Sharma Fahad Khan Moon Nyeo Park Bonglee Kim Bonglee Kim |
| author_sort | Pratibha Pandey |
| collection | DOAJ |
| description | Nuclear factor-κB (NF-κB) cell signaling pathway is essential for the progression and development of numerous human disorders, including cancer. NF-κB signaling pathway regulates a wide range of physiological processes, such as cell survival, growth, and migration. Deregulated NF-kB signaling resulted in unregulated cell proliferation, viability, movement, and invasion, thus promoting tumor development. Recent findings have increasingly shown that plant derived phytochemicals that inhibit NF-κB signaling have the potential to be employed in cancer therapeutics. Flavonoids are a group of polyphenolic natural compounds present in various plants and their fruits, vegetables, and leaves. These compounds have numerous medicinal properties owing to their antioxidant, anti-inflammatory, antiviral, and antitumor characteristics. The main mechanism by which these flavonoids exhibit their anticancer potential is via potent antioxidative and immunomodulatory actions. Current research reports have demonstrated that these flavonoids exhibited their anticancer effects via suppressing the NF-κB signaling. Based on these facts, we have comprehensively outlined the cancer promoting role of NF-κB pathway in various processes including tumor progression, drug resistance, angiogenesis and metastasis. In addition to these, we also summarize the anticancer potential of flavonoids by specifically targeting the NF-κB pathway in various types of cancers. |
| format | Article |
| id | doaj-art-6a5a4dd8ef044dc38f565522e5207f71 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-6a5a4dd8ef044dc38f565522e5207f712025-01-06T06:59:33ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.15134221513422An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathwayPratibha Pandey0Sorabh Lakhanpal1Danish Mahmood2Han Na Kang3Byunggyu Kim4Sojin Kang5Jinwon Choi6Min Choi7Shivam Pandey8Mahakshit Bhat9Shilpa Sharma10Fahad Khan11Moon Nyeo Park12Bonglee Kim13Bonglee Kim14Centre for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, Punjab, IndiaSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, IndiaDepartment of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, Saudi ArabiaKM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of KoreaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaSchool of Applied and Life Sciences, Uttaranchal University, Dehradun, IndiaDepartment of Medicine, National Institute of Medical Sciences, NIMS University Rajasthan, Jaipur, IndiaChandigarh Pharmacy College, Chandigarh Group of Colleges-Jhanjeri, Mohali, Punjab, IndiaCenter for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Chennai, IndiaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaKM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of KoreaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaNuclear factor-κB (NF-κB) cell signaling pathway is essential for the progression and development of numerous human disorders, including cancer. NF-κB signaling pathway regulates a wide range of physiological processes, such as cell survival, growth, and migration. Deregulated NF-kB signaling resulted in unregulated cell proliferation, viability, movement, and invasion, thus promoting tumor development. Recent findings have increasingly shown that plant derived phytochemicals that inhibit NF-κB signaling have the potential to be employed in cancer therapeutics. Flavonoids are a group of polyphenolic natural compounds present in various plants and their fruits, vegetables, and leaves. These compounds have numerous medicinal properties owing to their antioxidant, anti-inflammatory, antiviral, and antitumor characteristics. The main mechanism by which these flavonoids exhibit their anticancer potential is via potent antioxidative and immunomodulatory actions. Current research reports have demonstrated that these flavonoids exhibited their anticancer effects via suppressing the NF-κB signaling. Based on these facts, we have comprehensively outlined the cancer promoting role of NF-κB pathway in various processes including tumor progression, drug resistance, angiogenesis and metastasis. In addition to these, we also summarize the anticancer potential of flavonoids by specifically targeting the NF-κB pathway in various types of cancers.https://www.frontiersin.org/articles/10.3389/fphar.2024.1513422/fullflavonoidsnatural compoundsNF-kBsignaling/signaling pathwaysanticancer |
| spellingShingle | Pratibha Pandey Sorabh Lakhanpal Danish Mahmood Han Na Kang Byunggyu Kim Sojin Kang Jinwon Choi Min Choi Shivam Pandey Mahakshit Bhat Shilpa Sharma Fahad Khan Moon Nyeo Park Bonglee Kim Bonglee Kim An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway Frontiers in Pharmacology flavonoids natural compounds NF-kB signaling/signaling pathways anticancer |
| title | An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway |
| title_full | An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway |
| title_fullStr | An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway |
| title_full_unstemmed | An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway |
| title_short | An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway |
| title_sort | updated review summarizing the anticancer potential of flavonoids via targeting nf kb pathway |
| topic | flavonoids natural compounds NF-kB signaling/signaling pathways anticancer |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1513422/full |
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