<i>Ent</i>-Kaurane Diterpenoids from <i>Coffea</i> Genus: An Update of Chemical Diversity and Biological Aspects
Coffee is one of the most important beverages in the world and is produced from <i>Coffea</i> spp. beans. Diterpenes with <i>ent</i>-kaurane backbones have been described in this genus, and substances such as cafestol and kahweol have been widely investigated, along with thei...
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2024-12-01
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| author | Víctor de C. Martins Maria Alice E. da Silva Valdir F. da Veiga Henrique M. G. Pereira Claudia M. de Rezende |
| author_facet | Víctor de C. Martins Maria Alice E. da Silva Valdir F. da Veiga Henrique M. G. Pereira Claudia M. de Rezende |
| author_sort | Víctor de C. Martins |
| collection | DOAJ |
| description | Coffee is one of the most important beverages in the world and is produced from <i>Coffea</i> spp. beans. Diterpenes with <i>ent</i>-kaurane backbones have been described in this genus, and substances such as cafestol and kahweol have been widely investigated, along with their derivatives and biological properties. Other coffee <i>ent</i>-kaurane diterpenoids have been reported with new perspectives on their biological activities. The aim of this review is to update the chemical diversity of <i>ent</i>-kaurane diterpenoids in green and roasted coffee, detailing each new compound and reporting its biological potential. A systematic review was performed using the bibliographic databases (SciFinder, Web of Science, ScienceDirect) and specific keywords such as “coffea diterpenes”, “coffee diterpenes”, “coffee ent-kaurane diterpenes” and “coffee diterpenoids”. Only articles related to the isolation of coffee <i>ent</i>-kaurane compounds were considered. A total of 146 compounds were related to <i>Coffea</i> spp. since the first report in 1932. Different chemical skeletons were observed, and these compounds were grouped as furan-type, oxidation-type, rearrangement-type, lacton-type, and lactam-type, among others. In general, the new coffee diterpenoids showed potential as antidiabetic, antidiapogenic, α-glucosidade inhibition, antiplatelet activity, and Cav.3 inhibitors agents, revealing the possibilities for the design, discovery, and development of new drugs. |
| format | Article |
| id | doaj-art-6a3ad7d41fe94117af73e4e5b8ccca5b |
| institution | Kabale University |
| issn | 1420-3049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-6a3ad7d41fe94117af73e4e5b8ccca5b2025-01-10T13:18:45ZengMDPI AGMolecules1420-30492024-12-013015910.3390/molecules30010059<i>Ent</i>-Kaurane Diterpenoids from <i>Coffea</i> Genus: An Update of Chemical Diversity and Biological AspectsVíctor de C. Martins0Maria Alice E. da Silva1Valdir F. da Veiga2Henrique M. G. Pereira3Claudia M. de Rezende4Aroma Analysis Laboratory (LAROMA), Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro 21941-909, BrazilAroma Analysis Laboratory (LAROMA), Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro 21941-909, BrazilChemistry Section, Military Institute of Engineering, Rio de Janeiro 22290-270, BrazilBrazilian Doping Control Laboratory (LBCD), Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro 21941-909, BrazilAroma Analysis Laboratory (LAROMA), Institute of Chemistry, Federal University of Rio de Janeiro, Rio de Janeiro 21941-909, BrazilCoffee is one of the most important beverages in the world and is produced from <i>Coffea</i> spp. beans. Diterpenes with <i>ent</i>-kaurane backbones have been described in this genus, and substances such as cafestol and kahweol have been widely investigated, along with their derivatives and biological properties. Other coffee <i>ent</i>-kaurane diterpenoids have been reported with new perspectives on their biological activities. The aim of this review is to update the chemical diversity of <i>ent</i>-kaurane diterpenoids in green and roasted coffee, detailing each new compound and reporting its biological potential. A systematic review was performed using the bibliographic databases (SciFinder, Web of Science, ScienceDirect) and specific keywords such as “coffea diterpenes”, “coffee diterpenes”, “coffee ent-kaurane diterpenes” and “coffee diterpenoids”. Only articles related to the isolation of coffee <i>ent</i>-kaurane compounds were considered. A total of 146 compounds were related to <i>Coffea</i> spp. since the first report in 1932. Different chemical skeletons were observed, and these compounds were grouped as furan-type, oxidation-type, rearrangement-type, lacton-type, and lactam-type, among others. In general, the new coffee diterpenoids showed potential as antidiabetic, antidiapogenic, α-glucosidade inhibition, antiplatelet activity, and Cav.3 inhibitors agents, revealing the possibilities for the design, discovery, and development of new drugs.https://www.mdpi.com/1420-3049/30/1/59coffeagreen and roasted coffee<i>ent</i>-kauranenew compoundsantidiabetic potential |
| spellingShingle | Víctor de C. Martins Maria Alice E. da Silva Valdir F. da Veiga Henrique M. G. Pereira Claudia M. de Rezende <i>Ent</i>-Kaurane Diterpenoids from <i>Coffea</i> Genus: An Update of Chemical Diversity and Biological Aspects Molecules coffea green and roasted coffee <i>ent</i>-kaurane new compounds antidiabetic potential |
| title | <i>Ent</i>-Kaurane Diterpenoids from <i>Coffea</i> Genus: An Update of Chemical Diversity and Biological Aspects |
| title_full | <i>Ent</i>-Kaurane Diterpenoids from <i>Coffea</i> Genus: An Update of Chemical Diversity and Biological Aspects |
| title_fullStr | <i>Ent</i>-Kaurane Diterpenoids from <i>Coffea</i> Genus: An Update of Chemical Diversity and Biological Aspects |
| title_full_unstemmed | <i>Ent</i>-Kaurane Diterpenoids from <i>Coffea</i> Genus: An Update of Chemical Diversity and Biological Aspects |
| title_short | <i>Ent</i>-Kaurane Diterpenoids from <i>Coffea</i> Genus: An Update of Chemical Diversity and Biological Aspects |
| title_sort | i ent i kaurane diterpenoids from i coffea i genus an update of chemical diversity and biological aspects |
| topic | coffea green and roasted coffee <i>ent</i>-kaurane new compounds antidiabetic potential |
| url | https://www.mdpi.com/1420-3049/30/1/59 |
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