<i>Ent</i>-Kaurane Diterpenoids from <i>Coffea</i> Genus: An Update of Chemical Diversity and Biological Aspects
Coffee is one of the most important beverages in the world and is produced from <i>Coffea</i> spp. beans. Diterpenes with <i>ent</i>-kaurane backbones have been described in this genus, and substances such as cafestol and kahweol have been widely investigated, along with thei...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/1/59 |
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| Summary: | Coffee is one of the most important beverages in the world and is produced from <i>Coffea</i> spp. beans. Diterpenes with <i>ent</i>-kaurane backbones have been described in this genus, and substances such as cafestol and kahweol have been widely investigated, along with their derivatives and biological properties. Other coffee <i>ent</i>-kaurane diterpenoids have been reported with new perspectives on their biological activities. The aim of this review is to update the chemical diversity of <i>ent</i>-kaurane diterpenoids in green and roasted coffee, detailing each new compound and reporting its biological potential. A systematic review was performed using the bibliographic databases (SciFinder, Web of Science, ScienceDirect) and specific keywords such as “coffea diterpenes”, “coffee diterpenes”, “coffee ent-kaurane diterpenes” and “coffee diterpenoids”. Only articles related to the isolation of coffee <i>ent</i>-kaurane compounds were considered. A total of 146 compounds were related to <i>Coffea</i> spp. since the first report in 1932. Different chemical skeletons were observed, and these compounds were grouped as furan-type, oxidation-type, rearrangement-type, lacton-type, and lactam-type, among others. In general, the new coffee diterpenoids showed potential as antidiabetic, antidiapogenic, α-glucosidade inhibition, antiplatelet activity, and Cav.3 inhibitors agents, revealing the possibilities for the design, discovery, and development of new drugs. |
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| ISSN: | 1420-3049 |