Development of a cell-based target engagement assay for pyruvate dehydrogenase kinase

Development of a cell-based target engagement assay for pyruvate dehydrogenase kinase

Pyruvate dehydrogenase kinases (PDHKs) are non-canonical serine/threonine kinases that regulate the pyruvate dehydrogenase complex. Given their central role in metabolism, dysregulation of PDHKs has been linked with a broad variety of pathological conditions, such as cardiovascular disease, diabetes...

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Bibliographic Details
Main Authors: Mya D. Gough, Matthew B. Robers, Cesear R. Corona, Ranjit K. Mehta, Mukesh K. Nyati, Peter L. Toogood
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:SLAS Discovery
Subjects:
Pyruvate dehydrogenase kinase
Target engagement
NanoBRET
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555225000206
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