Primate-specific 82-kDa choline acetyltransferase attenuates progression of Alzheimer’s disease-like pathology in the APPNL-G-F knock-in mouse model

Primate-specific 82-kDa choline acetyltransferase attenuates progression of Alzheimer’s disease-like pathology in the APPNL-G-F knock-in mouse model

Abstract Alzheimer’s disease (AD) is characterized by amyloidosis, neuroinflammation, cholinergic dysfunction and cognitive impairment. In AD, the cholinergic neuronal marker choline acetyltransferase (ChAT) is reduced and the primate-specific nuclear isoform, 82-kDa ChAT, is mislocalized to cytopla...

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Bibliographic Details
Main Authors: Hadir E. AlQot, Rebecca Jane Rylett
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
82-kDa choline acetyltransferase
APPNL-G-F mice
Alzheimer’s disease
β-Amyloid clearance
Microglia
Neurobehavioral testing
Online Access:https://doi.org/10.1038/s41598-024-78751-2
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