Genome mining and biosynthetic pathways of marine-derived fungal bioactive natural products
Marine fungal natural products (MFNPs) are a vital source of pharmaceuticals, primarily synthesized by relevant biosynthetic gene clusters (BGCs). However, many of these BGCs remain silent under standard laboratory culture conditions, delaying the development of novel drugs from MFNPs to some extent...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-12-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1520446/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846127015974928384 |
|---|---|
| author | Caihua Han Anjing Song Yueying He Liu Yang Litong Chen Wei Dai Qilin Wu Siwen Yuan |
| author_facet | Caihua Han Anjing Song Yueying He Liu Yang Litong Chen Wei Dai Qilin Wu Siwen Yuan |
| author_sort | Caihua Han |
| collection | DOAJ |
| description | Marine fungal natural products (MFNPs) are a vital source of pharmaceuticals, primarily synthesized by relevant biosynthetic gene clusters (BGCs). However, many of these BGCs remain silent under standard laboratory culture conditions, delaying the development of novel drugs from MFNPs to some extent. This review highlights recent efforts in genome mining and biosynthetic pathways of bioactive natural products from marine fungi, focusing on methods such as bioinformatics analysis, gene knockout, and heterologous expression to identify relevant BGCs and elucidate the biosynthetic pathways and enzyme functions of MFNPs. The research efforts presented in this review provide essential insights for future gene-guided mining and biosynthetic pathway analysis in MFNPs. |
| format | Article |
| id | doaj-art-69fea48d505944b5b7db0116cb4da111 |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-69fea48d505944b5b7db0116cb4da1112024-12-12T06:18:25ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-12-011510.3389/fmicb.2024.15204461520446Genome mining and biosynthetic pathways of marine-derived fungal bioactive natural productsCaihua Han0Anjing Song1Yueying He2Liu Yang3Litong Chen4Wei Dai5Qilin Wu6Siwen Yuan7School of Bioengineering, Zunyi Medical University, Zhuhai, ChinaSchool of Bioengineering, Zunyi Medical University, Zhuhai, ChinaSchool of Bioengineering, Zunyi Medical University, Zhuhai, ChinaSchool of Bioengineering, Zunyi Medical University, Zhuhai, ChinaCenter of Ocean Expedition, School of Atmospheric Science, Sun Yat-sen University, Zhuhai, ChinaTeaching and Experimental Center, Guangdong Pharmaceutical University, Guangzhou, ChinaSchool of Bioengineering, Zunyi Medical University, Zhuhai, ChinaSchool of Bioengineering, Zunyi Medical University, Zhuhai, ChinaMarine fungal natural products (MFNPs) are a vital source of pharmaceuticals, primarily synthesized by relevant biosynthetic gene clusters (BGCs). However, many of these BGCs remain silent under standard laboratory culture conditions, delaying the development of novel drugs from MFNPs to some extent. This review highlights recent efforts in genome mining and biosynthetic pathways of bioactive natural products from marine fungi, focusing on methods such as bioinformatics analysis, gene knockout, and heterologous expression to identify relevant BGCs and elucidate the biosynthetic pathways and enzyme functions of MFNPs. The research efforts presented in this review provide essential insights for future gene-guided mining and biosynthetic pathway analysis in MFNPs.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1520446/fullmarine fungimarine natural productsbiosynthetic gene clustersgenome miningbiosynthesis |
| spellingShingle | Caihua Han Anjing Song Yueying He Liu Yang Litong Chen Wei Dai Qilin Wu Siwen Yuan Genome mining and biosynthetic pathways of marine-derived fungal bioactive natural products Frontiers in Microbiology marine fungi marine natural products biosynthetic gene clusters genome mining biosynthesis |
| title | Genome mining and biosynthetic pathways of marine-derived fungal bioactive natural products |
| title_full | Genome mining and biosynthetic pathways of marine-derived fungal bioactive natural products |
| title_fullStr | Genome mining and biosynthetic pathways of marine-derived fungal bioactive natural products |
| title_full_unstemmed | Genome mining and biosynthetic pathways of marine-derived fungal bioactive natural products |
| title_short | Genome mining and biosynthetic pathways of marine-derived fungal bioactive natural products |
| title_sort | genome mining and biosynthetic pathways of marine derived fungal bioactive natural products |
| topic | marine fungi marine natural products biosynthetic gene clusters genome mining biosynthesis |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1520446/full |
| work_keys_str_mv | AT caihuahan genomeminingandbiosyntheticpathwaysofmarinederivedfungalbioactivenaturalproducts AT anjingsong genomeminingandbiosyntheticpathwaysofmarinederivedfungalbioactivenaturalproducts AT yueyinghe genomeminingandbiosyntheticpathwaysofmarinederivedfungalbioactivenaturalproducts AT liuyang genomeminingandbiosyntheticpathwaysofmarinederivedfungalbioactivenaturalproducts AT litongchen genomeminingandbiosyntheticpathwaysofmarinederivedfungalbioactivenaturalproducts AT weidai genomeminingandbiosyntheticpathwaysofmarinederivedfungalbioactivenaturalproducts AT qilinwu genomeminingandbiosyntheticpathwaysofmarinederivedfungalbioactivenaturalproducts AT siwenyuan genomeminingandbiosyntheticpathwaysofmarinederivedfungalbioactivenaturalproducts |