Spherical nucleic acids for biomedical applications
Spherical nucleic acids (SNAs) are a 3D spherical nanostructure composed of highly oriented, dense layers of oligonucleotides conjugated to a hollow or solid core. This structure allows SNAs to show resistance to nuclease degradation, enter into nearly all cells without transfection agents and enabl...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Advanced Sensor and Energy Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2773045X24000281 |
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| _version_ | 1846151766229385216 |
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| author | Chunxin Xia Hemei Cheng Xinwei Hou Yu Zhang Xinchi Zhou Qinglong Yan Shuting Cao |
| author_facet | Chunxin Xia Hemei Cheng Xinwei Hou Yu Zhang Xinchi Zhou Qinglong Yan Shuting Cao |
| author_sort | Chunxin Xia |
| collection | DOAJ |
| description | Spherical nucleic acids (SNAs) are a 3D spherical nanostructure composed of highly oriented, dense layers of oligonucleotides conjugated to a hollow or solid core. This structure allows SNAs to show resistance to nuclease degradation, enter into nearly all cells without transfection agents and enable precise interactions with target molecules. Based on superior biological properties, SNAs can be tailored for diverse biological applications, rendering them a flexible and biosafe tool for biological applications as well as an enabling platform for therapy. In this review, we mainly discuss the structure and conjugation mode of SNAs and focus on recent advances in their applications, such as biomedical detection, imaging, and drug delivery. Finally, the remaining challenges and future directions of SNAs are also discussed and proposed. |
| format | Article |
| id | doaj-art-69fe3b7bbe7146edb0e4fefbd7e86c19 |
| institution | Kabale University |
| issn | 2773-045X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advanced Sensor and Energy Materials |
| spelling | doaj-art-69fe3b7bbe7146edb0e4fefbd7e86c192024-11-27T05:04:06ZengElsevierAdvanced Sensor and Energy Materials2773-045X2024-12-0134100117Spherical nucleic acids for biomedical applicationsChunxin Xia0Hemei Cheng1Xinwei Hou2Yu Zhang3Xinchi Zhou4Qinglong Yan5Shuting Cao6Jiaxing Key Laboratory of Bio-semiconductor, Xiangfu Laboratory, Jiashan 314102, ChinaJiaxing Key Laboratory of Bio-semiconductor, Xiangfu Laboratory, Jiashan 314102, ChinaJiaxing Key Laboratory of Bio-semiconductor, Xiangfu Laboratory, Jiashan 314102, ChinaThe Interdisciplinary Research Center, Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, ChinaJiaxing Key Laboratory of Bio-semiconductor, Xiangfu Laboratory, Jiashan 314102, ChinaJiaxing Key Laboratory of Bio-semiconductor, Xiangfu Laboratory, Jiashan 314102, China; Nano-translational Medicine Research Center, Yangtze Delta Region Institute of Tsinghua University, Jiaxing 314000, China; Corresponding authors.Jiaxing Key Laboratory of Bio-semiconductor, Xiangfu Laboratory, Jiashan 314102, China; Nano-translational Medicine Research Center, Yangtze Delta Region Institute of Tsinghua University, Jiaxing 314000, China; Corresponding authors.Spherical nucleic acids (SNAs) are a 3D spherical nanostructure composed of highly oriented, dense layers of oligonucleotides conjugated to a hollow or solid core. This structure allows SNAs to show resistance to nuclease degradation, enter into nearly all cells without transfection agents and enable precise interactions with target molecules. Based on superior biological properties, SNAs can be tailored for diverse biological applications, rendering them a flexible and biosafe tool for biological applications as well as an enabling platform for therapy. In this review, we mainly discuss the structure and conjugation mode of SNAs and focus on recent advances in their applications, such as biomedical detection, imaging, and drug delivery. Finally, the remaining challenges and future directions of SNAs are also discussed and proposed.http://www.sciencedirect.com/science/article/pii/S2773045X24000281Spherical nucleic acidsConjugation modeBiomedical detectionImagingDrug delivery |
| spellingShingle | Chunxin Xia Hemei Cheng Xinwei Hou Yu Zhang Xinchi Zhou Qinglong Yan Shuting Cao Spherical nucleic acids for biomedical applications Advanced Sensor and Energy Materials Spherical nucleic acids Conjugation mode Biomedical detection Imaging Drug delivery |
| title | Spherical nucleic acids for biomedical applications |
| title_full | Spherical nucleic acids for biomedical applications |
| title_fullStr | Spherical nucleic acids for biomedical applications |
| title_full_unstemmed | Spherical nucleic acids for biomedical applications |
| title_short | Spherical nucleic acids for biomedical applications |
| title_sort | spherical nucleic acids for biomedical applications |
| topic | Spherical nucleic acids Conjugation mode Biomedical detection Imaging Drug delivery |
| url | http://www.sciencedirect.com/science/article/pii/S2773045X24000281 |
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