Analyzing prognosis and comparing predictive scoring systems for mortality of COVID-19 patients with liver cirrhosis: a multicenter retrospective study
Abstract Background Limited research suggested that liver cirrhosis is an independent risk factor for severe COVID-19, leading to higher hospitalization and mortality rates. This study aimed to identify the prognostic factors and validate scoring systems for predicting mortality in COVID-19 patients...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-11-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-024-10223-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846158742973841408 |
|---|---|
| author | Shou-Yen Chen Chip-Jin Ng Yan-Bo Huang Hsiang-Yun Lo |
| author_facet | Shou-Yen Chen Chip-Jin Ng Yan-Bo Huang Hsiang-Yun Lo |
| author_sort | Shou-Yen Chen |
| collection | DOAJ |
| description | Abstract Background Limited research suggested that liver cirrhosis is an independent risk factor for severe COVID-19, leading to higher hospitalization and mortality rates. This study aimed to identify the prognostic factors and validate scoring systems for predicting mortality in COVID-19 patients with liver cirrhosis. Methods This retrospective cohort study extracted electronic health records of patients with COVID-19 who visited the emergency department between April 2021 and September 2022. Adult COVID-19 patients with liver cirrhosis were included, excluding those aged < 18 years and who did not require hospitalization. The primary outcome was in-hospital mortality. The effectiveness of the scoring systems were analyzed for COVID-19 in-house mortality prediction. Results A total of 1,368 adult COVID-19 patients with liver cirrhosis were included in this study. Compared with the survival group, the non-survival group had lower vital signs such as systolic blood pressure and blood oxygen saturation, higher levels of white blood cells, creatinine, bilirubin, and C-reactive protein, and longer prothrombin time. Higher rates of intubation, oxygen use, and dexamethasone use were observed in the non-survivor group. The WHO ordinal scale, MELD, and MELD-Na scores showed good predictive ability for in-hospital mortality. Conclusions The WHO ordinal scale showed the best performance in predicting mortality in patients with cirrhosis and COVID-19. MELD and MELD-Na scores were also found good performance for mortality prediction. Coagulation function, intubation, and dexamethasone administration were the most significant prognostic factors. |
| format | Article |
| id | doaj-art-69fdb268a39f49c9a9cf34d0623b2365 |
| institution | Kabale University |
| issn | 1471-2334 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-69fdb268a39f49c9a9cf34d0623b23652024-11-24T12:12:46ZengBMCBMC Infectious Diseases1471-23342024-11-012411910.1186/s12879-024-10223-4Analyzing prognosis and comparing predictive scoring systems for mortality of COVID-19 patients with liver cirrhosis: a multicenter retrospective studyShou-Yen Chen0Chip-Jin Ng1Yan-Bo Huang2Hsiang-Yun Lo3Department of Emergency Medicine, Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Emergency Medicine, Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Emergency Medicine, Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Emergency Medicine, Chang Gung Memorial Hospital, Chang Gung University College of MedicineAbstract Background Limited research suggested that liver cirrhosis is an independent risk factor for severe COVID-19, leading to higher hospitalization and mortality rates. This study aimed to identify the prognostic factors and validate scoring systems for predicting mortality in COVID-19 patients with liver cirrhosis. Methods This retrospective cohort study extracted electronic health records of patients with COVID-19 who visited the emergency department between April 2021 and September 2022. Adult COVID-19 patients with liver cirrhosis were included, excluding those aged < 18 years and who did not require hospitalization. The primary outcome was in-hospital mortality. The effectiveness of the scoring systems were analyzed for COVID-19 in-house mortality prediction. Results A total of 1,368 adult COVID-19 patients with liver cirrhosis were included in this study. Compared with the survival group, the non-survival group had lower vital signs such as systolic blood pressure and blood oxygen saturation, higher levels of white blood cells, creatinine, bilirubin, and C-reactive protein, and longer prothrombin time. Higher rates of intubation, oxygen use, and dexamethasone use were observed in the non-survivor group. The WHO ordinal scale, MELD, and MELD-Na scores showed good predictive ability for in-hospital mortality. Conclusions The WHO ordinal scale showed the best performance in predicting mortality in patients with cirrhosis and COVID-19. MELD and MELD-Na scores were also found good performance for mortality prediction. Coagulation function, intubation, and dexamethasone administration were the most significant prognostic factors.https://doi.org/10.1186/s12879-024-10223-4COVID-19Liver cirrhosisMortalityMELD scoreMELD-Na scoreWHO ordinal scale |
| spellingShingle | Shou-Yen Chen Chip-Jin Ng Yan-Bo Huang Hsiang-Yun Lo Analyzing prognosis and comparing predictive scoring systems for mortality of COVID-19 patients with liver cirrhosis: a multicenter retrospective study BMC Infectious Diseases COVID-19 Liver cirrhosis Mortality MELD score MELD-Na score WHO ordinal scale |
| title | Analyzing prognosis and comparing predictive scoring systems for mortality of COVID-19 patients with liver cirrhosis: a multicenter retrospective study |
| title_full | Analyzing prognosis and comparing predictive scoring systems for mortality of COVID-19 patients with liver cirrhosis: a multicenter retrospective study |
| title_fullStr | Analyzing prognosis and comparing predictive scoring systems for mortality of COVID-19 patients with liver cirrhosis: a multicenter retrospective study |
| title_full_unstemmed | Analyzing prognosis and comparing predictive scoring systems for mortality of COVID-19 patients with liver cirrhosis: a multicenter retrospective study |
| title_short | Analyzing prognosis and comparing predictive scoring systems for mortality of COVID-19 patients with liver cirrhosis: a multicenter retrospective study |
| title_sort | analyzing prognosis and comparing predictive scoring systems for mortality of covid 19 patients with liver cirrhosis a multicenter retrospective study |
| topic | COVID-19 Liver cirrhosis Mortality MELD score MELD-Na score WHO ordinal scale |
| url | https://doi.org/10.1186/s12879-024-10223-4 |
| work_keys_str_mv | AT shouyenchen analyzingprognosisandcomparingpredictivescoringsystemsformortalityofcovid19patientswithlivercirrhosisamulticenterretrospectivestudy AT chipjinng analyzingprognosisandcomparingpredictivescoringsystemsformortalityofcovid19patientswithlivercirrhosisamulticenterretrospectivestudy AT yanbohuang analyzingprognosisandcomparingpredictivescoringsystemsformortalityofcovid19patientswithlivercirrhosisamulticenterretrospectivestudy AT hsiangyunlo analyzingprognosisandcomparingpredictivescoringsystemsformortalityofcovid19patientswithlivercirrhosisamulticenterretrospectivestudy |