The role of the tryptophan metabolites in gut microbiota-brain axis and potential treatments: a focus on ischemic stroke
Gut microbiota disturbances can elevate the risk of stroke by contributing to cerebrovascular events. Particularly, the gut tryptophan (TRP) metabolite is an essential mediator of the gut-brain axis. This review highlights the role of TRP metabolism in stroke, the influence of intestinal microbiomes...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1578018/full |
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| author | Na Qin Xiaodi Xie Rong Deng Shiman Gao Ting Zhu |
| author_facet | Na Qin Xiaodi Xie Rong Deng Shiman Gao Ting Zhu |
| author_sort | Na Qin |
| collection | DOAJ |
| description | Gut microbiota disturbances can elevate the risk of stroke by contributing to cerebrovascular events. Particularly, the gut tryptophan (TRP) metabolite is an essential mediator of the gut-brain axis. This review highlights the role of TRP metabolism in stroke, the influence of intestinal microbiomes on stroke pathology via TRP metabolism, and the gut-brain axis interactions. Recent studies indicate that various bioactive molecules produced via TRP metabolism can regulate various neurological functions and interrupt stroke pathophysiology. Moreover, the relationship between gut TRP metabolism and stroke development has been verified. TRP metabolism involves three pathways: kynurenine, 5-hydroxytryptamine, and indole, which potentially regulate post-stroke, may function as aryl hydrocarbon receptor agonists to modify neuronal excitotoxicity, and offer crucial targets for stroke treatment. This suggests that modulating TRP metabolite levels through various methods can enhance the prognosis of central nervous system diseases and restore microbiota-gut-brain axis functions. |
| format | Article |
| id | doaj-art-69f40eb1c04a45c59328d66d7c209533 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-69f40eb1c04a45c59328d66d7c2095332025-08-20T03:44:55ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-06-011610.3389/fphar.2025.15780181578018The role of the tryptophan metabolites in gut microbiota-brain axis and potential treatments: a focus on ischemic strokeNa Qin0Xiaodi Xie1Rong Deng2Shiman Gao3Ting Zhu4Institute of Neuroregeneration & Neurorehabilitation, Qingdao Medical College, Qingdao University, Qingdao, ChinaInstitute of Neuroregeneration & Neurorehabilitation, Qingdao Medical College, Qingdao University, Qingdao, ChinaInstitute of Neuroregeneration & Neurorehabilitation, Qingdao Medical College, Qingdao University, Qingdao, ChinaWomen and Children’s Hospital, Qingdao University, Qingdao, ChinaInstitute of Neuroregeneration & Neurorehabilitation, Qingdao Medical College, Qingdao University, Qingdao, ChinaGut microbiota disturbances can elevate the risk of stroke by contributing to cerebrovascular events. Particularly, the gut tryptophan (TRP) metabolite is an essential mediator of the gut-brain axis. This review highlights the role of TRP metabolism in stroke, the influence of intestinal microbiomes on stroke pathology via TRP metabolism, and the gut-brain axis interactions. Recent studies indicate that various bioactive molecules produced via TRP metabolism can regulate various neurological functions and interrupt stroke pathophysiology. Moreover, the relationship between gut TRP metabolism and stroke development has been verified. TRP metabolism involves three pathways: kynurenine, 5-hydroxytryptamine, and indole, which potentially regulate post-stroke, may function as aryl hydrocarbon receptor agonists to modify neuronal excitotoxicity, and offer crucial targets for stroke treatment. This suggests that modulating TRP metabolite levels through various methods can enhance the prognosis of central nervous system diseases and restore microbiota-gut-brain axis functions.https://www.frontiersin.org/articles/10.3389/fphar.2025.1578018/fulltryptophan metabolitesgut microbiotamicrobiota-gut-brain axisischemic strokekynurenine |
| spellingShingle | Na Qin Xiaodi Xie Rong Deng Shiman Gao Ting Zhu The role of the tryptophan metabolites in gut microbiota-brain axis and potential treatments: a focus on ischemic stroke Frontiers in Pharmacology tryptophan metabolites gut microbiota microbiota-gut-brain axis ischemic stroke kynurenine |
| title | The role of the tryptophan metabolites in gut microbiota-brain axis and potential treatments: a focus on ischemic stroke |
| title_full | The role of the tryptophan metabolites in gut microbiota-brain axis and potential treatments: a focus on ischemic stroke |
| title_fullStr | The role of the tryptophan metabolites in gut microbiota-brain axis and potential treatments: a focus on ischemic stroke |
| title_full_unstemmed | The role of the tryptophan metabolites in gut microbiota-brain axis and potential treatments: a focus on ischemic stroke |
| title_short | The role of the tryptophan metabolites in gut microbiota-brain axis and potential treatments: a focus on ischemic stroke |
| title_sort | role of the tryptophan metabolites in gut microbiota brain axis and potential treatments a focus on ischemic stroke |
| topic | tryptophan metabolites gut microbiota microbiota-gut-brain axis ischemic stroke kynurenine |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1578018/full |
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