Anti-inflammatory and analgesic effects of Filipendula ulmaria extract
The present study investigated the chemical content, analgesic, and anti-inflammatory properties of Filipendula ulmaria (L.) Maxim. (meadowsweet) aerial part extract. F. ulmaria is native to Bulgaria. Based on its phytochemicals, meadowsweet has a vast range of pharmacological activities, like antip...
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2025-01-01
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| Series: | Pharmacia |
| Online Access: | https://pharmacia.pensoft.net/article/141286/download/pdf/ |
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| author | Lyubomir Marinov Georgi Momekov Yulian Voynikov Dimitrina Zheleva-Dimitrova Reneta Gevrenova Vessela Balabanova Iliya Mangarov Irina Nikolova |
| author_facet | Lyubomir Marinov Georgi Momekov Yulian Voynikov Dimitrina Zheleva-Dimitrova Reneta Gevrenova Vessela Balabanova Iliya Mangarov Irina Nikolova |
| author_sort | Lyubomir Marinov |
| collection | DOAJ |
| description | The present study investigated the chemical content, analgesic, and anti-inflammatory properties of Filipendula ulmaria (L.) Maxim. (meadowsweet) aerial part extract. F. ulmaria is native to Bulgaria. Based on its phytochemicals, meadowsweet has a vast range of pharmacological activities, like antipyretic, analgesic, anti-inflammatory, antirheumatic, immunostimulating, anti-microbial, anti-allergic, and gastroprotective activity. In our experiment, F. ulmaria aerial part extract was practically non-toxic (oral LD50 > 2000 mg/kg). The performed experiments revealed that diclofenac possesses better anti-inflammatory and antinociceptive activity than F. ulmaria extracts (100 and 200 mg/kg). The results revealed a dose-dependent moderate inhibition of the inflammation and pain induced by 3 days of oral pretreatment with methanolic extract of F. ulmaria extracts. No additive effect of FUA extracts on the effects of diclofenac was noted. F. ulmaria extracts did not induce any alterations in blood biochemical analysis. |
| format | Article |
| id | doaj-art-69d781273acc47db9454e5287335b21d |
| institution | Kabale University |
| issn | 2603-557X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Pharmacia |
| spelling | doaj-art-69d781273acc47db9454e5287335b21d2025-01-15T08:30:53ZengPensoft PublishersPharmacia2603-557X2025-01-017211110.3897/pharmacia.72.e141286141286Anti-inflammatory and analgesic effects of Filipendula ulmaria extractLyubomir Marinov0Georgi Momekov1Yulian Voynikov2Dimitrina Zheleva-Dimitrova3Reneta Gevrenova4Vessela Balabanova5Iliya Mangarov6Irina Nikolova7Medical University of SofiaMedical University of SofiaMedical University of SofiaMedical University of SofiaMedical University of SofiaMedical University of SofiaMedical University of SofiaMedical University of SofiaThe present study investigated the chemical content, analgesic, and anti-inflammatory properties of Filipendula ulmaria (L.) Maxim. (meadowsweet) aerial part extract. F. ulmaria is native to Bulgaria. Based on its phytochemicals, meadowsweet has a vast range of pharmacological activities, like antipyretic, analgesic, anti-inflammatory, antirheumatic, immunostimulating, anti-microbial, anti-allergic, and gastroprotective activity. In our experiment, F. ulmaria aerial part extract was practically non-toxic (oral LD50 > 2000 mg/kg). The performed experiments revealed that diclofenac possesses better anti-inflammatory and antinociceptive activity than F. ulmaria extracts (100 and 200 mg/kg). The results revealed a dose-dependent moderate inhibition of the inflammation and pain induced by 3 days of oral pretreatment with methanolic extract of F. ulmaria extracts. No additive effect of FUA extracts on the effects of diclofenac was noted. F. ulmaria extracts did not induce any alterations in blood biochemical analysis.https://pharmacia.pensoft.net/article/141286/download/pdf/ |
| spellingShingle | Lyubomir Marinov Georgi Momekov Yulian Voynikov Dimitrina Zheleva-Dimitrova Reneta Gevrenova Vessela Balabanova Iliya Mangarov Irina Nikolova Anti-inflammatory and analgesic effects of Filipendula ulmaria extract Pharmacia |
| title | Anti-inflammatory and analgesic effects of Filipendula ulmaria extract |
| title_full | Anti-inflammatory and analgesic effects of Filipendula ulmaria extract |
| title_fullStr | Anti-inflammatory and analgesic effects of Filipendula ulmaria extract |
| title_full_unstemmed | Anti-inflammatory and analgesic effects of Filipendula ulmaria extract |
| title_short | Anti-inflammatory and analgesic effects of Filipendula ulmaria extract |
| title_sort | anti inflammatory and analgesic effects of filipendula ulmaria extract |
| url | https://pharmacia.pensoft.net/article/141286/download/pdf/ |
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