Elevated plasma p-tau231 is associated with reduced generalization and medial temporal lobe dynamic network flexibility among healthy older African Americans

Elevated plasma p-tau231 is associated with reduced generalization and medial temporal lobe dynamic network flexibility among healthy older African Americans

Abstract Background Phosphorylated tau (p-tau) and amyloid beta (Aβ) in human plasma may provide an affordable and minimally invasive method to evaluate Alzheimer’s disease (AD) pathophysiology. The medial temporal lobe (MTL) is susceptible to changes in structural integrity that are indicative of t...

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Main Authors: Miray Budak, Bernadette A. Fausto, Zuzanna Osiecka, Mustafa Sheikh, Robert Perna, Nicholas Ashton, Kaj Blennow, Henrik Zetterberg, Patricia Fitzgerald-Bocarsly, Mark A. Gluck
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Alzheimer’s Research & Therapy
Subjects:
Plasma p-tau
Amyloid-beta
Medial temporal lobe
Dynamic flexibility
Generalization
African Americans
Online Access:https://doi.org/10.1186/s13195-024-01619-0
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