CATS: a bioinformatic tool for automated Cas9 nucleases activity comparison in clinically relevant contexts

CATS: a bioinformatic tool for automated Cas9 nucleases activity comparison in clinically relevant contexts

IntroductionWith the growing number of Cas9 nucleases available to genetic engineers, selecting the most suitable one for a given application can be challenging. A major complication arises from the differing protospacer adjacent motif (PAM) sequence requirements of each Cas9 variant, which makes di...

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Bibliographic Details
Main Authors: Ettore Rocchi, Federico Magnani, Gastone Castellani, Antonio Carusillo, Martina Tarozzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Genome Editing
Subjects:
CRISPR/Cas9
PAM
bioinformatics
genome editing
bioinformatic software
PAM comparison
Online Access:https://www.frontiersin.org/articles/10.3389/fgeed.2025.1571023/full
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