Serum vascular endothelial growth factor levels in bitches with canine transmissible venereal tumors treated with vincristine sulphate
<b>Aim:</b> The present study aimed to determine the serum concentrations of vascular endothelial growth factor (VEGF), which is an important factor in tumor angiogenesis, in dogs with transmissible venereal tumor (TVT) and to evaluate the levels of this factor in treatment with vincrist...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
2021-06-01
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| Series: | Eurasian Journal of Veterinary Sciences |
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| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=1356 |
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| author | Esra Kocabaş Özkan Duru Hasan Ceyhun Macun |
| author_facet | Esra Kocabaş Özkan Duru Hasan Ceyhun Macun |
| author_sort | Esra Kocabaş |
| collection | DOAJ |
| description | <b>Aim:</b> The present study aimed to determine the serum concentrations of
vascular endothelial growth factor (VEGF), which is an important factor in
tumor angiogenesis, in dogs with transmissible venereal tumor (TVT) and
to evaluate the levels of this factor in treatment with vincristine sulphate.
On the other hand, the relationship between VEGF level and the number of
vincristine sulphate applications was investigated.<p>
<b>Materials and Methods: </b>Study material is consisted of twelve Kangal
Shepherds and its crossbreds without ovariohysterectomy (OHE) diagnosed
with TVT (study group)and 12 healthy Kangal Shepherds and its
crossbreds without OHE (control group). Blood was drawn from 12 dogs
included in the study group before each treatment and one week after the
end of the treatment. Blood was drawn once from the dogs in the control
group.<p>
<b>Results:</b> All cases in the study group were treated with 3-8 (4,33±1,43)
vincristine sulphate administrations. Three of the patients recovered with
3, 6 of the dogs with 4, 1 with 5, 1 with 6 administrations and 1 with 8
weeks of administrations. In the correlation analysis that performed between
the pre-treatment serum VEGF level and the number of vincristine
sulphate administration, a statistically in significant positive correlation
was found (r = 0,051). When serum VEGF values of dogs in the study group
were compared with the pre-treatment serum VEGF values of dogs in the
control group, no statistical difference was found (p = 0,160).<p>
<b>Conclusion:</b> As a result, although serum VEGF values of dogs with TVT
were higher than healthy dogs, it was determined that there was no statistical
difference. No correlation was found between pre-treatment serum
VEGF value and number of applications. |
| format | Article |
| id | doaj-art-69baef67bf0d409f89e6e9b591ecbcb2 |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publishDate | 2021-06-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-69baef67bf0d409f89e6e9b591ecbcb22025-01-02T22:36:23ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19532021-06-013721301361356Serum vascular endothelial growth factor levels in bitches with canine transmissible venereal tumors treated with vincristine sulphateEsra Kocabaş0Özkan Duru1Hasan Ceyhun Macun2Kırıkkale Üniversitesi Veteriner Fakültesi Doğum ve Jinekoloji Anabilim Dalı, Kırıkkale, TürkiyeKırıkkale Üniversitesi Veteriner Fakültesi Biyokimya Anabilim Dalı, Kırıkkale, TürkiyeKırıkkale Üniversitesi Veteriner Fakültesi Doğum ve Jinekoloji Anabilim Dalı, Kırıkkale, Türkiye<b>Aim:</b> The present study aimed to determine the serum concentrations of vascular endothelial growth factor (VEGF), which is an important factor in tumor angiogenesis, in dogs with transmissible venereal tumor (TVT) and to evaluate the levels of this factor in treatment with vincristine sulphate. On the other hand, the relationship between VEGF level and the number of vincristine sulphate applications was investigated.<p> <b>Materials and Methods: </b>Study material is consisted of twelve Kangal Shepherds and its crossbreds without ovariohysterectomy (OHE) diagnosed with TVT (study group)and 12 healthy Kangal Shepherds and its crossbreds without OHE (control group). Blood was drawn from 12 dogs included in the study group before each treatment and one week after the end of the treatment. Blood was drawn once from the dogs in the control group.<p> <b>Results:</b> All cases in the study group were treated with 3-8 (4,33±1,43) vincristine sulphate administrations. Three of the patients recovered with 3, 6 of the dogs with 4, 1 with 5, 1 with 6 administrations and 1 with 8 weeks of administrations. In the correlation analysis that performed between the pre-treatment serum VEGF level and the number of vincristine sulphate administration, a statistically in significant positive correlation was found (r = 0,051). When serum VEGF values of dogs in the study group were compared with the pre-treatment serum VEGF values of dogs in the control group, no statistical difference was found (p = 0,160).<p> <b>Conclusion:</b> As a result, although serum VEGF values of dogs with TVT were higher than healthy dogs, it was determined that there was no statistical difference. No correlation was found between pre-treatment serum VEGF value and number of applications.http://eurasianjvetsci.org/pdf.php3?id=1356angiogenesiscaninetvtvegfvincristine sulphate |
| spellingShingle | Esra Kocabaş Özkan Duru Hasan Ceyhun Macun Serum vascular endothelial growth factor levels in bitches with canine transmissible venereal tumors treated with vincristine sulphate Eurasian Journal of Veterinary Sciences angiogenesis canine tvt vegf vincristine sulphate |
| title | Serum vascular endothelial growth factor levels in bitches with canine transmissible venereal tumors treated with vincristine sulphate |
| title_full | Serum vascular endothelial growth factor levels in bitches with canine transmissible venereal tumors treated with vincristine sulphate |
| title_fullStr | Serum vascular endothelial growth factor levels in bitches with canine transmissible venereal tumors treated with vincristine sulphate |
| title_full_unstemmed | Serum vascular endothelial growth factor levels in bitches with canine transmissible venereal tumors treated with vincristine sulphate |
| title_short | Serum vascular endothelial growth factor levels in bitches with canine transmissible venereal tumors treated with vincristine sulphate |
| title_sort | serum vascular endothelial growth factor levels in bitches with canine transmissible venereal tumors treated with vincristine sulphate |
| topic | angiogenesis canine tvt vegf vincristine sulphate |
| url | http://eurasianjvetsci.org/pdf.php3?id=1356 |
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