Sensing the squeeze: nuclear mechanotransduction in health and disease
The nucleus not only is a repository for DNA but also a center of cellular and nuclear mechanotransduction. From nuclear deformation to the interplay between mechanosensing components and genetic control, the nucleus is poised at the nexus of mechanical forces and cellular function. Understanding th...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Nucleus |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19491034.2024.2374854 |
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| author | Luv Kishore Srivastava Allen J. Ehrlicher |
| author_facet | Luv Kishore Srivastava Allen J. Ehrlicher |
| author_sort | Luv Kishore Srivastava |
| collection | DOAJ |
| description | The nucleus not only is a repository for DNA but also a center of cellular and nuclear mechanotransduction. From nuclear deformation to the interplay between mechanosensing components and genetic control, the nucleus is poised at the nexus of mechanical forces and cellular function. Understanding the stresses acting on the nucleus, its mechanical properties, and their effects on gene expression is therefore crucial to appreciate its mechanosensitive function. In this review, we examine many elements of nuclear mechanotransduction, and discuss the repercussions on the health of cells and states of illness. By describing the processes that underlie nuclear mechanosensation and analyzing its effects on gene regulation, the review endeavors to open new avenues for studying nuclear mechanics in physiology and diseases. |
| format | Article |
| id | doaj-art-69b0f1644f2b4919a922f43fa0f9bbef |
| institution | Kabale University |
| issn | 1949-1034 1949-1042 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Nucleus |
| spelling | doaj-art-69b0f1644f2b4919a922f43fa0f9bbef2024-12-09T07:27:14ZengTaylor & Francis GroupNucleus1949-10341949-10422024-12-0115110.1080/19491034.2024.2374854Sensing the squeeze: nuclear mechanotransduction in health and diseaseLuv Kishore Srivastava0Allen J. Ehrlicher1Department of Bioengineering, McGill University, Montreal, CanadaDepartment of Bioengineering, McGill University, Montreal, CanadaThe nucleus not only is a repository for DNA but also a center of cellular and nuclear mechanotransduction. From nuclear deformation to the interplay between mechanosensing components and genetic control, the nucleus is poised at the nexus of mechanical forces and cellular function. Understanding the stresses acting on the nucleus, its mechanical properties, and their effects on gene expression is therefore crucial to appreciate its mechanosensitive function. In this review, we examine many elements of nuclear mechanotransduction, and discuss the repercussions on the health of cells and states of illness. By describing the processes that underlie nuclear mechanosensation and analyzing its effects on gene regulation, the review endeavors to open new avenues for studying nuclear mechanics in physiology and diseases.https://www.tandfonline.com/doi/10.1080/19491034.2024.2374854Chromatinlamin A/CLINC complexmechanotransductionnuclear deformation |
| spellingShingle | Luv Kishore Srivastava Allen J. Ehrlicher Sensing the squeeze: nuclear mechanotransduction in health and disease Nucleus Chromatin lamin A/C LINC complex mechanotransduction nuclear deformation |
| title | Sensing the squeeze: nuclear mechanotransduction in health and disease |
| title_full | Sensing the squeeze: nuclear mechanotransduction in health and disease |
| title_fullStr | Sensing the squeeze: nuclear mechanotransduction in health and disease |
| title_full_unstemmed | Sensing the squeeze: nuclear mechanotransduction in health and disease |
| title_short | Sensing the squeeze: nuclear mechanotransduction in health and disease |
| title_sort | sensing the squeeze nuclear mechanotransduction in health and disease |
| topic | Chromatin lamin A/C LINC complex mechanotransduction nuclear deformation |
| url | https://www.tandfonline.com/doi/10.1080/19491034.2024.2374854 |
| work_keys_str_mv | AT luvkishoresrivastava sensingthesqueezenuclearmechanotransductioninhealthanddisease AT allenjehrlicher sensingthesqueezenuclearmechanotransductioninhealthanddisease |