Combined drug delivery and treatment monitoring using a single high frequency ultrasound system
Ultrasound-mediated drug delivery is typically performed using transducers with center frequencies [Formula: see text]1 MHz to promote acoustic cavitation. Such frequencies are not commonly used for diagnostic ultrasound due to limited spatial resolution. Therefore, delivery and monitoring of therap...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2430330 |
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| author | Yesna O. Yildiz Jia-Ling Ruan Michael D. Gray Luca Bau Richard J. Browning Christophoros Mannaris Anne E. Kiltie Borivoj Vojnovic Eleanor Stride |
| author_facet | Yesna O. Yildiz Jia-Ling Ruan Michael D. Gray Luca Bau Richard J. Browning Christophoros Mannaris Anne E. Kiltie Borivoj Vojnovic Eleanor Stride |
| author_sort | Yesna O. Yildiz |
| collection | DOAJ |
| description | Ultrasound-mediated drug delivery is typically performed using transducers with center frequencies [Formula: see text]1 MHz to promote acoustic cavitation. Such frequencies are not commonly used for diagnostic ultrasound due to limited spatial resolution. Therefore, delivery and monitoring of therapeutic ultrasound typically requires two transducers to enable both treatment and imaging. This study investigates the feasibility of using a single commercial ultrasound imaging transducer operating at 5 MHz for both drug delivery and real-time imaging. We compared a single-transducer system (STS) at 5 MHz with a conventional dual-transducer system (DTS) using a 1.1 MHz therapeutic transducer and an imaging probe. in vitro experiments demonstrated that the STS could achieve comparable extravasation depth and area as the DTS, with higher drug deposition observed at 5 MHz. Additionally, extravasation patterns were influenced by peak negative pressure (PNP) and duty cycle, with the narrower beam width at 5 MHz offering potential advantages for targeted drug delivery. in vivo experiments in a murine bladder cancer model confirmed the efficacy of the STS for real-time imaging and drug delivery, with cavitation dose correlating with drug deposition. The results suggest that a single-transducer approach may enhance the precision and efficiency of ultrasound-mediated drug delivery, potentially reducing system complexity and cost. |
| format | Article |
| id | doaj-art-69a4ac5b3dc2401e99317626fa6e072b |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj-art-69a4ac5b3dc2401e99317626fa6e072b2025-01-03T09:30:28ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2430330Combined drug delivery and treatment monitoring using a single high frequency ultrasound systemYesna O. Yildiz0Jia-Ling Ruan1Michael D. Gray2Luca Bau3Richard J. Browning4Christophoros Mannaris5Anne E. Kiltie6Borivoj Vojnovic7Eleanor Stride8Department of Oncology, University of Oxford, Oxford, UKDepartment of Oncology, University of Oxford, Oxford, UKBiomedical Ultrasonics, Biotherapy and Biopharmaceuticals Laboratory (BUBBL), Institute of Biomedical Engineering, University of Oxford, Oxford, UKBiomedical Ultrasonics, Biotherapy and Biopharmaceuticals Laboratory (BUBBL), Institute of Biomedical Engineering, University of Oxford, Oxford, UKDepartment of Oncology, University of Oxford, Oxford, UKBiomedical Ultrasonics, Biotherapy and Biopharmaceuticals Laboratory (BUBBL), Institute of Biomedical Engineering, University of Oxford, Oxford, UKDepartment of Oncology, University of Oxford, Oxford, UKDepartment of Oncology, University of Oxford, Oxford, UKBiomedical Ultrasonics, Biotherapy and Biopharmaceuticals Laboratory (BUBBL), Institute of Biomedical Engineering, University of Oxford, Oxford, UKUltrasound-mediated drug delivery is typically performed using transducers with center frequencies [Formula: see text]1 MHz to promote acoustic cavitation. Such frequencies are not commonly used for diagnostic ultrasound due to limited spatial resolution. Therefore, delivery and monitoring of therapeutic ultrasound typically requires two transducers to enable both treatment and imaging. This study investigates the feasibility of using a single commercial ultrasound imaging transducer operating at 5 MHz for both drug delivery and real-time imaging. We compared a single-transducer system (STS) at 5 MHz with a conventional dual-transducer system (DTS) using a 1.1 MHz therapeutic transducer and an imaging probe. in vitro experiments demonstrated that the STS could achieve comparable extravasation depth and area as the DTS, with higher drug deposition observed at 5 MHz. Additionally, extravasation patterns were influenced by peak negative pressure (PNP) and duty cycle, with the narrower beam width at 5 MHz offering potential advantages for targeted drug delivery. in vivo experiments in a murine bladder cancer model confirmed the efficacy of the STS for real-time imaging and drug delivery, with cavitation dose correlating with drug deposition. The results suggest that a single-transducer approach may enhance the precision and efficiency of ultrasound-mediated drug delivery, potentially reducing system complexity and cost.https://www.tandfonline.com/doi/10.1080/02656736.2024.2430330theranosticultrasound-mediated drug deliveryimage-guided therapymicrobubblescavitation |
| spellingShingle | Yesna O. Yildiz Jia-Ling Ruan Michael D. Gray Luca Bau Richard J. Browning Christophoros Mannaris Anne E. Kiltie Borivoj Vojnovic Eleanor Stride Combined drug delivery and treatment monitoring using a single high frequency ultrasound system International Journal of Hyperthermia theranostic ultrasound-mediated drug delivery image-guided therapy microbubbles cavitation |
| title | Combined drug delivery and treatment monitoring using a single high frequency ultrasound system |
| title_full | Combined drug delivery and treatment monitoring using a single high frequency ultrasound system |
| title_fullStr | Combined drug delivery and treatment monitoring using a single high frequency ultrasound system |
| title_full_unstemmed | Combined drug delivery and treatment monitoring using a single high frequency ultrasound system |
| title_short | Combined drug delivery and treatment monitoring using a single high frequency ultrasound system |
| title_sort | combined drug delivery and treatment monitoring using a single high frequency ultrasound system |
| topic | theranostic ultrasound-mediated drug delivery image-guided therapy microbubbles cavitation |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2430330 |
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