The reverse transsulfuration pathway affects the colonic microbiota and contributes to colitis in mice

The reverse transsulfuration pathway affects the colonic microbiota and contributes to colitis in mice

Abstract Cystathionine γ-lyase (CTH) is a critical enzyme in the reverse transsulfuration pathway, the major route for the metabolism of sulfur-containing amino acids, notably converting cystathionine to cysteine. We reported that CTH supports gastritis induced by the pathogen Helicobacter pylori. H...

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Bibliographic Details
Main Authors: Alain P. Gobert, Yvonne L. Latour, Kara M. McNamara, Caroline V. Hawkins, Kamery J. Williams, Mohammad Asim, Daniel P. Barry, Margaret M. Allaman, Alberto G. Delgado, Ginger L. Milne, Shilin Zhao, M. Blanca Piazuelo, M. Kay Washington, Lori A. Coburn, Keith T. Wilson
Format: Article
Language:English
Published: Springer 2024-10-01
Series:Amino Acids
Subjects:
Cystathionine g-lyase
Inflammatory bowel disease
Colitis
Colitis-associated carcinogenesis
Cysteine
Gut microbiota
Online Access:https://doi.org/10.1007/s00726-024-03423-4
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