Stem cell-derived exosome delivery systems for treating atherosclerosis: The new frontier of stem cell therapy
Cardiovascular diseases (CVDs) are a leading cause of mortality worldwide. As a chronic inflammatory disease with a complicated pathophysiology marked by abnormal lipid metabolism and arterial plaque formation, atherosclerosis is a major contributor to CVDs and can induce abrupt cardiac events. The...
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Elsevier
2025-02-01
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| Series: | Materials Today Bio |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424005015 |
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| author | Hassan Tariq Syeda Zunaira Bukhari Ruibing An Jian Dong Ayesha Ihsan Muhammad Rizwan Younis |
| author_facet | Hassan Tariq Syeda Zunaira Bukhari Ruibing An Jian Dong Ayesha Ihsan Muhammad Rizwan Younis |
| author_sort | Hassan Tariq |
| collection | DOAJ |
| description | Cardiovascular diseases (CVDs) are a leading cause of mortality worldwide. As a chronic inflammatory disease with a complicated pathophysiology marked by abnormal lipid metabolism and arterial plaque formation, atherosclerosis is a major contributor to CVDs and can induce abrupt cardiac events. The discovery of exosomes' role in intercellular communication has sparked a great deal of interest in them recently. Exosomes are involved in strategic phases of the onset and development of atherosclerosis because they have been identified to control pathophysiologic pathways including inflammation, angiogenesis, or senescence. This review investigates the potential role of stem cell-derived exosomes in atherosclerosis management. We briefly introduced atherosclerosis and stem cell therapy including stem cell-derived exosomes. The biogenesis of exosomes along with their secretion and isolation have been elaborated. The design engineering of exosomes has been summarized to present how drug loading and surface modification with targeting ligands can improve the therapeutic and targeting capacity of exosomes, demonstrating atheroprotective action. Moreover, the mechanism of action (endothelial dysfunction, reduction of dyslipidemia, macrophage polarization, vascular calcification, and angiogenesis) of drug-loaded exosomes to treat atherosclerosis has been discussed in detail. In the end, a comparative and balanced viewpoint has been given regarding the current challenges and potential solutions to advance exosome engineering for cardiovascular therapeutic applications. |
| format | Article |
| id | doaj-art-696cdda26b7d4274b015668dbb29761e |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-696cdda26b7d4274b015668dbb29761e2025-01-17T04:52:14ZengElsevierMaterials Today Bio2590-00642025-02-0130101440Stem cell-derived exosome delivery systems for treating atherosclerosis: The new frontier of stem cell therapyHassan Tariq0Syeda Zunaira Bukhari1Ruibing An2Jian Dong3Ayesha Ihsan4Muhammad Rizwan Younis5Institute of Optical Functional Materials for Biomedical Imaging, School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Science, Taian, Shandong, 271016, PR China; Department of Chemical and Biomolecular Engineering, University of California - Los Angeles, Los Angeles, CA, 90095, USA; National Institute for Biotechnology and Genetic Engineering College, Pakistan Institute of Engineering and Applied Sciences (NIBGE-C, PIEAS), Faisalabad, Pakistan; Department of Molecular, Cell and Developmental Biology, University of California - Los Angeles, Los Angeles, CA, 90095, USANational Institute for Biotechnology and Genetic Engineering College, Pakistan Institute of Engineering and Applied Sciences (NIBGE-C, PIEAS), Faisalabad, PakistanInstitute of Optical Functional Materials for Biomedical Imaging, School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Science, Taian, Shandong, 271016, PR China; Corresponding author. Institute of Optical Functional Materials for Biomedical Imaging, School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Science, Taian, Shandong 271016, PR China.Institute of Optical Functional Materials for Biomedical Imaging, School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Science, Taian, Shandong, 271016, PR China; Corresponding authors.National Institute for Biotechnology and Genetic Engineering College, Pakistan Institute of Engineering and Applied Sciences (NIBGE-C, PIEAS), Faisalabad, Pakistan; Corresponding author.Institute of Optical Functional Materials for Biomedical Imaging, School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Science, Taian, Shandong, 271016, PR China; Department of Chemical and Biomolecular Engineering, University of California - Los Angeles, Los Angeles, CA, 90095, USA; Corresponding authors. Institute of Optical Functional Materials for Biomedical Imaging, School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Science, Taian, Shandong 271016, PR China.Cardiovascular diseases (CVDs) are a leading cause of mortality worldwide. As a chronic inflammatory disease with a complicated pathophysiology marked by abnormal lipid metabolism and arterial plaque formation, atherosclerosis is a major contributor to CVDs and can induce abrupt cardiac events. The discovery of exosomes' role in intercellular communication has sparked a great deal of interest in them recently. Exosomes are involved in strategic phases of the onset and development of atherosclerosis because they have been identified to control pathophysiologic pathways including inflammation, angiogenesis, or senescence. This review investigates the potential role of stem cell-derived exosomes in atherosclerosis management. We briefly introduced atherosclerosis and stem cell therapy including stem cell-derived exosomes. The biogenesis of exosomes along with their secretion and isolation have been elaborated. The design engineering of exosomes has been summarized to present how drug loading and surface modification with targeting ligands can improve the therapeutic and targeting capacity of exosomes, demonstrating atheroprotective action. Moreover, the mechanism of action (endothelial dysfunction, reduction of dyslipidemia, macrophage polarization, vascular calcification, and angiogenesis) of drug-loaded exosomes to treat atherosclerosis has been discussed in detail. In the end, a comparative and balanced viewpoint has been given regarding the current challenges and potential solutions to advance exosome engineering for cardiovascular therapeutic applications.http://www.sciencedirect.com/science/article/pii/S2590006424005015 |
| spellingShingle | Hassan Tariq Syeda Zunaira Bukhari Ruibing An Jian Dong Ayesha Ihsan Muhammad Rizwan Younis Stem cell-derived exosome delivery systems for treating atherosclerosis: The new frontier of stem cell therapy Materials Today Bio |
| title | Stem cell-derived exosome delivery systems for treating atherosclerosis: The new frontier of stem cell therapy |
| title_full | Stem cell-derived exosome delivery systems for treating atherosclerosis: The new frontier of stem cell therapy |
| title_fullStr | Stem cell-derived exosome delivery systems for treating atherosclerosis: The new frontier of stem cell therapy |
| title_full_unstemmed | Stem cell-derived exosome delivery systems for treating atherosclerosis: The new frontier of stem cell therapy |
| title_short | Stem cell-derived exosome delivery systems for treating atherosclerosis: The new frontier of stem cell therapy |
| title_sort | stem cell derived exosome delivery systems for treating atherosclerosis the new frontier of stem cell therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424005015 |
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