Hollow Fiber Microreactor Combined with Digital Twin to Optimize the Antimicrobial Evaluation Process

Hollow Fiber Microreactor Combined with Digital Twin to Optimize the Antimicrobial Evaluation Process

In order to reproduce pharmacokinetics (PK) profiles seen in vivo, the Hollow Fiber Infection Model (HFIM) is a useful in vitro module in the evaluation of antimicrobial resistance. In order to reduce the consumption of culture medium and drugs, we developed a hollow fiber microreactor applicable to...

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Bibliographic Details
Main Authors: Kazuhiro Noda, Toshihiro Kasama, Marie Shinohara, Masakaze Hamada, Yukiko T. Matsunaga, Madoka Takai, Yoshikazu Ishii, Ryo Miyake
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Micromachines
Subjects:
antimicrobial resistance
fluidics
miniaturization
numerical simulation
Online Access:https://www.mdpi.com/2072-666X/15/12/1517
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https://www.mdpi.com/2072-666X/15/12/1517

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