Development of a homotrimeric PSMA radioligand based on the NOTI chelating platform

Development of a homotrimeric PSMA radioligand based on the NOTI chelating platform

Abstract Background The NOTI chelating scaffold can readily be derivatized for bioconjugation without impacting its metal complexation/radiolabeling properties making it an attractive building block for the development of multimeric/-valent radiopharmaceuticals. The objective of the study was to fur...

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Bibliographic Details
Main Authors: Sebastian Martin, Moritz-Valentin Schreck, Tobias Stemler, Stephan Maus, Florian Rosar, Caroline Burgard, Andrea Schaefer-Schuler, Samer Ezziddin, Mark D. Bartholomä
Format: Article
Language:English
Published: SpringerOpen 2024-12-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
NOTI
Bifunctional chelator
Gallium-68
PSMA
Trimer
Multimerization
Online Access:https://doi.org/10.1186/s41181-024-00314-7
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