Design and Evaluation of Pyridinyl Sulfonyl Piperazine LpxH Inhibitors with Potent Antibiotic Activity Against Enterobacterales

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Main Authors: Amanda F. Ennis, C. Skyler Cochrane, Patrick A. Dome, Pyeonghwa Jeong, Jincheng Yu, Hyejin Lee, Carly S. Williams, Yang Ha, Weitao Yang, Pei Zhou, Jiyong Hong
Format: Article
Language:English
Published: American Chemical Society 2024-11-01
Series:JACS Au
Online Access:https://doi.org/10.1021/jacsau.4c00731
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author Amanda F. Ennis
C. Skyler Cochrane
Patrick A. Dome
Pyeonghwa Jeong
Jincheng Yu
Hyejin Lee
Carly S. Williams
Yang Ha
Weitao Yang
Pei Zhou
Jiyong Hong
author_facet Amanda F. Ennis
C. Skyler Cochrane
Patrick A. Dome
Pyeonghwa Jeong
Jincheng Yu
Hyejin Lee
Carly S. Williams
Yang Ha
Weitao Yang
Pei Zhou
Jiyong Hong
author_sort Amanda F. Ennis
collection DOAJ
format Article
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institution Kabale University
issn 2691-3704
language English
publishDate 2024-11-01
publisher American Chemical Society
record_format Article
series JACS Au
spelling doaj-art-690a8e36230c4353b41dc07f81fda4512024-11-25T08:40:22ZengAmerican Chemical SocietyJACS Au2691-37042024-11-014114383439310.1021/jacsau.4c00731Design and Evaluation of Pyridinyl Sulfonyl Piperazine LpxH Inhibitors with Potent Antibiotic Activity Against EnterobacteralesAmanda F. Ennis0C. Skyler Cochrane1Patrick A. Dome2Pyeonghwa Jeong3Jincheng Yu4Hyejin Lee5Carly S. Williams6Yang Ha7Weitao Yang8Pei Zhou9Jiyong Hong10Department of Chemistry, Duke University, Durham, North Carolina, United StatesDepartment of Chemistry, Duke University, Durham, North Carolina, United StatesDepartment of Chemistry, Duke University, Durham, North Carolina, United StatesDepartment of Chemistry, Duke University, Durham, North Carolina, United StatesDepartment of Chemistry, Duke University, Durham, North Carolina, United StatesDepartment of Chemistry, Duke University, Durham, North Carolina, United StatesDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina, United StatesBerkeley Center for Structural Biology, Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, California, United StatesDepartment of Chemistry, Duke University, Durham, North Carolina, United StatesDepartment of Chemistry, Duke University, Durham, North Carolina, United StatesDepartment of Chemistry, Duke University, Durham, North Carolina, United Stateshttps://doi.org/10.1021/jacsau.4c00731
spellingShingle Amanda F. Ennis
C. Skyler Cochrane
Patrick A. Dome
Pyeonghwa Jeong
Jincheng Yu
Hyejin Lee
Carly S. Williams
Yang Ha
Weitao Yang
Pei Zhou
Jiyong Hong
Design and Evaluation of Pyridinyl Sulfonyl Piperazine LpxH Inhibitors with Potent Antibiotic Activity Against Enterobacterales
JACS Au
title Design and Evaluation of Pyridinyl Sulfonyl Piperazine LpxH Inhibitors with Potent Antibiotic Activity Against Enterobacterales
title_full Design and Evaluation of Pyridinyl Sulfonyl Piperazine LpxH Inhibitors with Potent Antibiotic Activity Against Enterobacterales
title_fullStr Design and Evaluation of Pyridinyl Sulfonyl Piperazine LpxH Inhibitors with Potent Antibiotic Activity Against Enterobacterales
title_full_unstemmed Design and Evaluation of Pyridinyl Sulfonyl Piperazine LpxH Inhibitors with Potent Antibiotic Activity Against Enterobacterales
title_short Design and Evaluation of Pyridinyl Sulfonyl Piperazine LpxH Inhibitors with Potent Antibiotic Activity Against Enterobacterales
title_sort design and evaluation of pyridinyl sulfonyl piperazine lpxh inhibitors with potent antibiotic activity against enterobacterales
url https://doi.org/10.1021/jacsau.4c00731
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