Performance Evaluation of a Preclinical SPECT Scanner with a Collimator Designed for Medium-Sized Animals
Background. Equipped with two stationary detectors, a large bore collimator for medium-sized animals has been recently introduced for dedicated preclinical single-photon emission computed tomography (SPECT) imaging. We aimed to evaluate the basic performance of the system using phantoms and healthy...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-01-01
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| Series: | Molecular Imaging |
| Online Access: | http://dx.doi.org/10.1155/2022/9810097 |
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| author | Yohji Matsusaka Rudolf A. Werner Paula Arias-Loza Naoko Nose Takanori Sasaki Xinyu Chen Constantin Lapa Takahiro Higuchi |
| author_facet | Yohji Matsusaka Rudolf A. Werner Paula Arias-Loza Naoko Nose Takanori Sasaki Xinyu Chen Constantin Lapa Takahiro Higuchi |
| author_sort | Yohji Matsusaka |
| collection | DOAJ |
| description | Background. Equipped with two stationary detectors, a large bore collimator for medium-sized animals has been recently introduced for dedicated preclinical single-photon emission computed tomography (SPECT) imaging. We aimed to evaluate the basic performance of the system using phantoms and healthy rabbits. Methods. A general-purpose medium-sized animal (GP-MSA) collimator with 135 mm bore diameter and thirty-three holes of 2.5 mm diameter was installed on an ultrahigh-resolution scanner equipped with two large stationary detectors (U-SPECT5-E/CT). The sensitivity and uniformity were investigated using a point source and a cylinder phantom containing 99mTc-pertechnetate, respectively. Uniformity (in %) was derived using volumes of interest (VOIs) on images of the cylinder phantom and calculated as maximum count−minimum count/maximum count+minimum count×100, with lower values of % indicating superior performance. The spatial resolution and contrast-to-noise ratios (CNRs) were evaluated with images of a hot-rod Derenzo phantom using different activity concentrations. Feasibility of in vivo SPECT imaging was finally confirmed by rabbit imaging with the most commonly used clinical myocardial perfusion SPECT agent [99mTc]Tc-sestamibi (dynamic acquisition with a scan time of 5 min). Results. In the performance evaluation, a sensitivity of 790 cps/MBq, a spatial resolution with the hot-rod phantom of 2.5 mm, and a uniformity of 39.2% were achieved. The CNRs of the rod size 2.5 mm were 1.37, 1.24, 1.20, and 0.85 for activity concentration of 29.2, 1.0, 0.5, and 0.1 MBq/mL, respectively. Dynamic SPECT imaging in rabbits allowed to visualize most of the thorax and to generate time-activity curves of the left myocardial wall and ventricular cavity. Conclusion. Preclinical U-SPECT5-E/CT equipped with a large bore collimator demonstrated adequate sensitivity and resolution for in vivo rabbit imaging. Along with its unique features of SPECT molecular functional imaging is a superior collimator technology that is applicable to medium-sized animal models and thus may promote translational research for diagnostic purposes and development of novel therapeutics. |
| format | Article |
| id | doaj-art-68d64dd31b1749bb8f6b9c2510692477 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-68d64dd31b1749bb8f6b9c25106924772025-01-02T22:41:08ZengSAGE PublishingMolecular Imaging1536-01212022-01-01202210.1155/2022/9810097Performance Evaluation of a Preclinical SPECT Scanner with a Collimator Designed for Medium-Sized AnimalsYohji Matsusaka0Rudolf A. Werner1Paula Arias-Loza2Naoko Nose3Takanori Sasaki4Xinyu Chen5Constantin Lapa6Takahiro Higuchi7Department of Nuclear Medicine and Comprehensive Heart Failure CenterDepartment of Nuclear Medicine and Comprehensive Heart Failure CenterDepartment of Nuclear Medicine and Comprehensive Heart Failure CenterGraduate School of MedicineGraduate School of MedicineDepartment of Nuclear Medicine and Comprehensive Heart Failure CenterNuclear MedicineDepartment of Nuclear Medicine and Comprehensive Heart Failure CenterBackground. Equipped with two stationary detectors, a large bore collimator for medium-sized animals has been recently introduced for dedicated preclinical single-photon emission computed tomography (SPECT) imaging. We aimed to evaluate the basic performance of the system using phantoms and healthy rabbits. Methods. A general-purpose medium-sized animal (GP-MSA) collimator with 135 mm bore diameter and thirty-three holes of 2.5 mm diameter was installed on an ultrahigh-resolution scanner equipped with two large stationary detectors (U-SPECT5-E/CT). The sensitivity and uniformity were investigated using a point source and a cylinder phantom containing 99mTc-pertechnetate, respectively. Uniformity (in %) was derived using volumes of interest (VOIs) on images of the cylinder phantom and calculated as maximum count−minimum count/maximum count+minimum count×100, with lower values of % indicating superior performance. The spatial resolution and contrast-to-noise ratios (CNRs) were evaluated with images of a hot-rod Derenzo phantom using different activity concentrations. Feasibility of in vivo SPECT imaging was finally confirmed by rabbit imaging with the most commonly used clinical myocardial perfusion SPECT agent [99mTc]Tc-sestamibi (dynamic acquisition with a scan time of 5 min). Results. In the performance evaluation, a sensitivity of 790 cps/MBq, a spatial resolution with the hot-rod phantom of 2.5 mm, and a uniformity of 39.2% were achieved. The CNRs of the rod size 2.5 mm were 1.37, 1.24, 1.20, and 0.85 for activity concentration of 29.2, 1.0, 0.5, and 0.1 MBq/mL, respectively. Dynamic SPECT imaging in rabbits allowed to visualize most of the thorax and to generate time-activity curves of the left myocardial wall and ventricular cavity. Conclusion. Preclinical U-SPECT5-E/CT equipped with a large bore collimator demonstrated adequate sensitivity and resolution for in vivo rabbit imaging. Along with its unique features of SPECT molecular functional imaging is a superior collimator technology that is applicable to medium-sized animal models and thus may promote translational research for diagnostic purposes and development of novel therapeutics.http://dx.doi.org/10.1155/2022/9810097 |
| spellingShingle | Yohji Matsusaka Rudolf A. Werner Paula Arias-Loza Naoko Nose Takanori Sasaki Xinyu Chen Constantin Lapa Takahiro Higuchi Performance Evaluation of a Preclinical SPECT Scanner with a Collimator Designed for Medium-Sized Animals Molecular Imaging |
| title | Performance Evaluation of a Preclinical SPECT Scanner with a Collimator Designed for Medium-Sized Animals |
| title_full | Performance Evaluation of a Preclinical SPECT Scanner with a Collimator Designed for Medium-Sized Animals |
| title_fullStr | Performance Evaluation of a Preclinical SPECT Scanner with a Collimator Designed for Medium-Sized Animals |
| title_full_unstemmed | Performance Evaluation of a Preclinical SPECT Scanner with a Collimator Designed for Medium-Sized Animals |
| title_short | Performance Evaluation of a Preclinical SPECT Scanner with a Collimator Designed for Medium-Sized Animals |
| title_sort | performance evaluation of a preclinical spect scanner with a collimator designed for medium sized animals |
| url | http://dx.doi.org/10.1155/2022/9810097 |
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