Exploring the Influence of Age at Menarche on Metabolic Syndrome and Its Components Across Different Women's Birth Cohorts
ABSTRACT Purpose Metabolic syndrome (MetS) is the primary cardiovascular risk factor, making it a global issue. Our objective was to assess the association between the age at menarche (AAM) and MetS and its components in different generations of women. Methods In this cross‐sectional study, 5500 eli...
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| Format: | Article |
| Language: | English |
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Wiley
2024-11-01
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| Series: | Endocrinology, Diabetes & Metabolism |
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| Online Access: | https://doi.org/10.1002/edm2.70015 |
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| author | Maryam Farahmand Maryam Mousavi Fereidoun Azizi Fahimeh Ramezani Tehrani |
| author_facet | Maryam Farahmand Maryam Mousavi Fereidoun Azizi Fahimeh Ramezani Tehrani |
| author_sort | Maryam Farahmand |
| collection | DOAJ |
| description | ABSTRACT Purpose Metabolic syndrome (MetS) is the primary cardiovascular risk factor, making it a global issue. Our objective was to assess the association between the age at menarche (AAM) and MetS and its components in different generations of women. Methods In this cross‐sectional study, 5500 eligible women aged ≥ 20 who participated in the Tehran lipid and glucose study in 2015–2017 were selected. Participants were divided into groups by birth cohorts (BC) (born ≤ 1959, 1960–1979, and ≥ 1980) and AAM (≤ 11, 12–15, and ≥ 16 years, early, normal, and late, respectively). The status of MetS and its components were compared amongst participants using logistic regression. Results Normal AAM (12–15 years) was considered the reference group. The adjusted model revealed that AAM ≤ 11 is associated with a higher risk of 34% (95% confidence interval (CI): 1.04, 1.71) in MetS, and the prevalence of MetS in the early menarche group was higher in BCI, and BCII (odds ratio (OR): 1.87; 95% CI: 1.04, 3.36 and OR: 1.33; 95% CI: 1.00, 1.89, respectively). Those with late menarche demonstrated a lower risk (OR:0.72; 95% CI: 0.57, 0.91) of abdominal obesity, and early menarche showed a higher risk (OR: 1.45; CI: 1.14, 1.86). This higher risk in early menarche was observed in BCI and BCII (OR: 1.76; 95% CI: 1.16, 2.66 and OR: 1.80; 95% CI: 1.23, 2.64, respectively). However, the protective effect of late menarche was observed in BC II and BC III (OR: 0.74; 95% CI: 0.54, 1.00 and OR: 0.64; 95% CI: 0.44, 0.96, respectively). Conclusions The influential effect of AAM on metabolic disturbances varies amongst different generations. |
| format | Article |
| id | doaj-art-68d196ba94e148d6b724eafb88d19e3f |
| institution | Kabale University |
| issn | 2398-9238 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism |
| spelling | doaj-art-68d196ba94e148d6b724eafb88d19e3f2024-11-25T04:44:35ZengWileyEndocrinology, Diabetes & Metabolism2398-92382024-11-0176n/an/a10.1002/edm2.70015Exploring the Influence of Age at Menarche on Metabolic Syndrome and Its Components Across Different Women's Birth CohortsMaryam Farahmand0Maryam Mousavi1Fereidoun Azizi2Fahimeh Ramezani Tehrani3Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran IranReproductive Endocrinology Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran IranEndocrine Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran IranReproductive Endocrinology Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran IranABSTRACT Purpose Metabolic syndrome (MetS) is the primary cardiovascular risk factor, making it a global issue. Our objective was to assess the association between the age at menarche (AAM) and MetS and its components in different generations of women. Methods In this cross‐sectional study, 5500 eligible women aged ≥ 20 who participated in the Tehran lipid and glucose study in 2015–2017 were selected. Participants were divided into groups by birth cohorts (BC) (born ≤ 1959, 1960–1979, and ≥ 1980) and AAM (≤ 11, 12–15, and ≥ 16 years, early, normal, and late, respectively). The status of MetS and its components were compared amongst participants using logistic regression. Results Normal AAM (12–15 years) was considered the reference group. The adjusted model revealed that AAM ≤ 11 is associated with a higher risk of 34% (95% confidence interval (CI): 1.04, 1.71) in MetS, and the prevalence of MetS in the early menarche group was higher in BCI, and BCII (odds ratio (OR): 1.87; 95% CI: 1.04, 3.36 and OR: 1.33; 95% CI: 1.00, 1.89, respectively). Those with late menarche demonstrated a lower risk (OR:0.72; 95% CI: 0.57, 0.91) of abdominal obesity, and early menarche showed a higher risk (OR: 1.45; CI: 1.14, 1.86). This higher risk in early menarche was observed in BCI and BCII (OR: 1.76; 95% CI: 1.16, 2.66 and OR: 1.80; 95% CI: 1.23, 2.64, respectively). However, the protective effect of late menarche was observed in BC II and BC III (OR: 0.74; 95% CI: 0.54, 1.00 and OR: 0.64; 95% CI: 0.44, 0.96, respectively). Conclusions The influential effect of AAM on metabolic disturbances varies amongst different generations.https://doi.org/10.1002/edm2.70015generationslifestyle factorsmetabolic changesreproductive factors |
| spellingShingle | Maryam Farahmand Maryam Mousavi Fereidoun Azizi Fahimeh Ramezani Tehrani Exploring the Influence of Age at Menarche on Metabolic Syndrome and Its Components Across Different Women's Birth Cohorts Endocrinology, Diabetes & Metabolism generations lifestyle factors metabolic changes reproductive factors |
| title | Exploring the Influence of Age at Menarche on Metabolic Syndrome and Its Components Across Different Women's Birth Cohorts |
| title_full | Exploring the Influence of Age at Menarche on Metabolic Syndrome and Its Components Across Different Women's Birth Cohorts |
| title_fullStr | Exploring the Influence of Age at Menarche on Metabolic Syndrome and Its Components Across Different Women's Birth Cohorts |
| title_full_unstemmed | Exploring the Influence of Age at Menarche on Metabolic Syndrome and Its Components Across Different Women's Birth Cohorts |
| title_short | Exploring the Influence of Age at Menarche on Metabolic Syndrome and Its Components Across Different Women's Birth Cohorts |
| title_sort | exploring the influence of age at menarche on metabolic syndrome and its components across different women s birth cohorts |
| topic | generations lifestyle factors metabolic changes reproductive factors |
| url | https://doi.org/10.1002/edm2.70015 |
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