CD40 ligation-induced ERK activation leads to enhanced radiosensitivity in cervical carcinoma cells via promoting autophagy
CD40, a member of the tumor necrosis factor (TNF) receptor superfamily, plays an important role not only in the immune system but also in tumor progression. CD40 ligation reportedly promotes autophagy in immune cells. However, the effects of CD40 ligation on autophagy and its mechanism in solid tumo...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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China Science Publishing & Media Ltd.
2024-12-01
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| Series: | Acta Biochimica et Biophysica Sinica |
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| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2024229 |
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| _version_ | 1849234156117032960 |
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| author | Liu Baocai Zhang Yadong Wang Quan Wang Qian Wang Zhixin Feng Li |
| author_facet | Liu Baocai Zhang Yadong Wang Quan Wang Qian Wang Zhixin Feng Li |
| author_sort | Liu Baocai |
| collection | DOAJ |
| description | CD40, a member of the tumor necrosis factor (TNF) receptor superfamily, plays an important role not only in the immune system but also in tumor progression. CD40 ligation reportedly promotes autophagy in immune cells. However, the effects of CD40 ligation on autophagy and its mechanism in solid tumor cells are still unclear. In this study, we find that CD40 ligation promotes autophagosome formation and consequently promotes autophagic flux in cervical cancer cells. Mechanistically, this effect relies on ERK contributing to CD40 ligation-induced ATG13 upregulation by p53. Furthermore, we demonstrate that CD40 ligation-induced autophagy increases the radiosensitivity of cervical cancer cells. Taken together, our results provide new evidence for the involvement of the CD40 pathway in autophagy and radiotherapy in cervical cancer cells. |
| format | Article |
| id | doaj-art-68c6dd8fa9af4595a04da9fb4e820744 |
| institution | Kabale University |
| issn | 1672-9145 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj-art-68c6dd8fa9af4595a04da9fb4e8207442025-08-20T04:03:13ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452024-12-01571252125910.3724/abbs.202422920d259ccCD40 ligation-induced ERK activation leads to enhanced radiosensitivity in cervical carcinoma cells via promoting autophagyLiu Baocai0Zhang Yadong1Wang Quan2Wang Qian3Wang Zhixin4Feng Li5["Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun 130033, China"]["Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun 130033, China"]["Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun 130033, China"]["Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun 130033, China"]["Department of Urology, China-Japan Union Hospital of Jilin University, Changchun 130033, China"]["Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun 130033, China"]CD40, a member of the tumor necrosis factor (TNF) receptor superfamily, plays an important role not only in the immune system but also in tumor progression. CD40 ligation reportedly promotes autophagy in immune cells. However, the effects of CD40 ligation on autophagy and its mechanism in solid tumor cells are still unclear. In this study, we find that CD40 ligation promotes autophagosome formation and consequently promotes autophagic flux in cervical cancer cells. Mechanistically, this effect relies on ERK contributing to CD40 ligation-induced ATG13 upregulation by p53. Furthermore, we demonstrate that CD40 ligation-induced autophagy increases the radiosensitivity of cervical cancer cells. Taken together, our results provide new evidence for the involvement of the CD40 pathway in autophagy and radiotherapy in cervical cancer cells.https://www.sciengine.com/doi/10.3724/abbs.2024229CD40autophagyradiosensitivitycervical cancer |
| spellingShingle | Liu Baocai Zhang Yadong Wang Quan Wang Qian Wang Zhixin Feng Li CD40 ligation-induced ERK activation leads to enhanced radiosensitivity in cervical carcinoma cells via promoting autophagy Acta Biochimica et Biophysica Sinica CD40 autophagy radiosensitivity cervical cancer |
| title | CD40 ligation-induced ERK activation leads to enhanced radiosensitivity in cervical carcinoma cells via promoting autophagy |
| title_full | CD40 ligation-induced ERK activation leads to enhanced radiosensitivity in cervical carcinoma cells via promoting autophagy |
| title_fullStr | CD40 ligation-induced ERK activation leads to enhanced radiosensitivity in cervical carcinoma cells via promoting autophagy |
| title_full_unstemmed | CD40 ligation-induced ERK activation leads to enhanced radiosensitivity in cervical carcinoma cells via promoting autophagy |
| title_short | CD40 ligation-induced ERK activation leads to enhanced radiosensitivity in cervical carcinoma cells via promoting autophagy |
| title_sort | cd40 ligation induced erk activation leads to enhanced radiosensitivity in cervical carcinoma cells via promoting autophagy |
| topic | CD40 autophagy radiosensitivity cervical cancer |
| url | https://www.sciengine.com/doi/10.3724/abbs.2024229 |
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