THSG counteracts microglial glycolytic reprogramming and neuronal necroptosis both in vivo and in vitro under conditions of neuroinflammation

THSG counteracts microglial glycolytic reprogramming and neuronal necroptosis both in vivo and in vitro under conditions of neuroinflammation

Abstract Microglial activation, driven by a metabolic shift towards aerobic glycolysis, is implicated in neuroinflammation and neurological disorders like depression. THSG (2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside), derived from Polygonum multiflorum, exhibits anti-inflammatory and neuroprote...

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Bibliographic Details
Main Authors: Zhe Guo, Sijia Zhong, Jinpeng Bai, Xiuyuan Lang, Minmin Cao, Yang Hu, Xiaoyan Qin, Yingyu Sun
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
THSG
Neuroinflammation
Microglia
Metabolic reprogramming
Necroptosis
Depression
Online Access:https://doi.org/10.1038/s41598-025-05994-y
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